Clinical characteristics and outcomes of diabetic patients who were hospitalised with 2009 pandemic influenza A H1N1 infection
Clinical characteristics and outcomes of diabetic patients who were hospitalised with 2009 pandemic influenza A H1N1 infection
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DOI：
10.1016/j.jinf.2011.11.022
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发表时间：
2012-02-01
影响因子：
28.2
通讯作者：
Pachon, Isabel
中科院分区：
文献类型：
--
作者：
Cortes Garcia, Marta;Sierra Moros, Maria Jose;Pachon, Isabel
目的：描述糖尿病患者2009年甲型H1N1流感（pH1N1）感染重症病例的人口统计学和临床数据及结局。研究方法：我们从2009年6月至12月向西班牙监测系统报告的pH1N1检测的严重实验室确诊病例中选择了所有糖尿病患者（N = 252）。选择1例年龄和性别匹配的无糖尿病患者。收集的变量包括人口统计学特征，基础的医疗条件，结果，临床过程和treatment.Results：在那些患有糖尿病，只有15.9%没有报告任何其他基础条件。38%的糖尿病患者和27.4%的非糖尿病患者入住ICU（p = 0.008）。多因素分析显示，合并心血管疾病（OR = 2.28）、病态肥胖（OR = 2.08）和发病48 h后开始抗病毒治疗（OR = 1.89）是ICU住院或死亡的独立危险因素。患糖尿病不是ICU入院或死亡的独立危险因素调整后的协变量covariates.Conclusions：糖尿病患者的预后较差的结果可能是一个后果的高患病率的共病基础的医疗条件，但不是糖尿病本身。需要进一步的前瞻性研究来验证这些结果。(C)2011年，英国传染病协会。由爱思唯尔有限公司出版。保留所有权利。
Objectives: To describe demographic and clinical data and outcomes of severe cases of 2009 pandemic influenza A H1N1 (pH1N1) infections for persons with diabetes. Methods: We selected all person with diabetes (N = 252) among severe laboratory confirmed cases reported to the Spanish Surveillance System for detection of pH1N1 from June through December, 2009. One patient without diabetes matched by age and sex was selected. Collected variables included demographic characteristics, underlying medical conditions, outcome, clinical course and treatment.Results: Among those suffering diabetes only 15.9% did not report any other underlying condition. 38% of diabetic patients and 27.4% of non diabetic patients were admitted to ICU (p = 0.008). Thirty subjects suffering diabetes and fifteen without the disease died (11.9% vs. 6%[p = 0.019]).Multivariable analysis showed that the independent risk factors for ICU admission or death were suffering cardiovascular disease (OR = 2.28), morbid obesity (OR = 2.08) and antiviral treatment started after 48 h of onset of symptoms (OR = 1.89). Suffering diabetes was not independent risk factors for ICU admission or death after adjusting for covariates.Conclusions: The worse outcome among diabetes sufferers could be a consequence of the higher prevalence of comorbid underlying medical conditions but not diabetes itself. Further prospective studies are needed to verify these results. (C) 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved.