Biologic correlates of 18F-FDG uptake on PET in pulmonary pleomorphic carcinoma
Biologic correlates of 18F-FDG uptake on PET in pulmonary pleomorphic carcinoma
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DOI：
10.1016/j.lungcan.2010.05.021
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发表时间：
2011-02-01
期刊：
影响因子：
5.3
通讯作者：
Yamamoto, Nobuyuki
中科院分区：
文献类型：
--
作者：
Kaira, Kyoichi;Endo, Masahiro;Yamamoto, Nobuyuki
背景资料：肺多形性癌是一种罕见的上皮性肿瘤，关于2-[F-18]-氟-2-脱氧-D-葡萄糖（F-18-FDG）正电子发射断层扫描（PET）的有用性信息也知之甚少。因此，我们进行了这项研究，包括潜在的生物学分析F-18-FDG uptake.Methods：15例肺多形性癌谁接受F-18-FDG PET治疗前被纳入本研究。通过免疫组织化学对肿瘤切片进行葡萄糖转运蛋白1（Glut 1）、葡萄糖转运蛋白3（Glut 3）、缺氧诱导因子-1 α（HIF-1 α）、细胞增殖（Ki-67标记指数）、血管内皮生长因子（VEGF）、微血管（CD 34）、细胞周期控制标记物（p53）和凋亡标记物（bcl-2）染色。结果：15例非小细胞肺癌（NSCLC）患者的最大标准化摄取值（SUVmax）为6.1 ~ 26.8（中位数19.3）。F-18-FDG摄取与Glut 1（p = 0.0016）、Glut 3（p = 0.0080）、VEGF（p = 0.0048）和微血管密度（MVD）（p = 0.0005）呈正相关。HIF-1 α、p53和bcl-2与F-18-FDG摄取无明显相关性。结论：肺多形性癌F-18-FDG摄取与糖代谢（Glut 1、Glut 3）和血管生成（VEGF、MVD）密切相关。F18-FDG摄取与这些生物标志物之间的关系可能会导致肺多形性癌更合理地使用PET扫描。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Background: Pulmonary pleomorphic carcinoma is a rare epithelial tumor, and little is also known about the information on the usefulness of 2-[F-18]-fluoro-2-deoxy-D-glucose (F-18-FDG) positron emission tomography (PET). Therefore, we conducted the study including the underlying biologic analysis of F-18-FDG uptake.Methods: Fifteen patients with pulmonary pleomorphic carcinoma who underwent F-18-FDG PET before treatment were included in this study. Tumor sections were stained by immunohistochemistry for glucose transporter 1 (Glut1); glucose transporter 3 (Glut3); hypoxia-inducible factor-1 alpha (HIF-1 alpha); cell proliferation (Ki-67 labeling index); vascular endothelial growth factor (VEGF); microvessels (CD34); cell cycle control marker (p53); and apoptosis marker (bcl-2). These parameters were correlated with a control group of patients with other non-small cell lung cancer (NSCLC) (n = 33).Results: The maximal standardized uptake value (SUVmax) of the primary tumors in 15 patients ranged from 6.1 to 26.8 (median 19.3). There were positive correlation between F-18-FDG uptake and Glut1 (p = 0.0016), Glut3 (p = 0.0080), VEGF (p = 0.0048), and microvessel density (MVD) (p = 0.0005). HIF-1 alpha, p53 and bcl-2 showed no positive correlation with F-18-FDG uptake. F-18-FDG uptake, Glut1, Glut3, HIF-1 alpha, VEGF and Ki-67 were significantly higher in patients with pulmonary pleomorphic carcinoma than those with other NSCLC.Conclusion: F-18-FDG uptake in pulmonary pleomorphic carcinoma is closely associated with the presence of glucose metabolism (Glut1 and Glut3) and angiogenesis (VEGF and MVD). The relationship between F-18-FDG uptake and these biomarkers may lead to a more rational use of PET scan in pulmonary pleomorphic carcinoma. (C) 2010 Elsevier Ireland Ltd. All rights reserved.