Regulation of mammalian Ste20 (Mst) kinases.
Regulation of mammalian Ste20 (Mst) kinases.
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DOI：
10.1016/j.tibs.2015.01.001
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发表时间：
2015-03
影响因子：
13.8
通讯作者：
Chernoff, Jonathan
中科院分区：
文献类型：
--
作者：
Rawat, Sonali J.;Chernoff, Jonathan
Mst1/2激酶最初被认为是酵母Ste20激酶的哺乳动物同源物，在果蝇中作为Hippo肿瘤抑制途径的关键组分被重新发现后，被广泛研究。迄今为止，我们对Mst底物和下游信号的理解超过了我们对上游信号如何控制这些酶的了解。虽然关于Mst调控的机制还有很多有待发现，但很明显，Mst1激酶活性至少部分受其二聚化状态的控制，包括自结合和与各种其他信号伙伴的异源二聚化。在这里，我们回顾了Mst信号传导和功能的基本结构，并讨论了我们对这些重要激酶如何调节的理解的最新进展。
Initially identified as mammalian homologs to yeast Ste20 kinases, the Mst1/2 kinases have been widely investigated subsequent to their rediscovery as key components of the Hippo tumor suppressor pathway in flies. To date, our understanding of Mst substrates and downstream signaling outstrips our knowledge of how these enzymes are controlled by upstream signals. While much remains to be discovered regarding the mechanisms of Mst regulation, it is clear that Mst1 kinase activity is governed at least in part by its state of dimerization, including self-association and also heterodimerization with a variety of other signaling partners. Here, we review the basic architecture of Mst signaling and function and discuss recent advances in our understanding of how these important kinases are regulated.
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