Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma.

Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma.
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皮肤鳞状细胞癌的分子机制。

DOI:
10.3390/ijms23073478
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发表时间:
2022-03-23
影响因子:
5.6
通讯作者:
Seykora JT
Seykora JT
中科院分区:
生物学2区
文献类型:
--
作者:
Hedberg ML;Berry CT;Moshiri AS;Xiang Y;Yeh CJ;Attilasoy C;Capell BC;Seykora JT

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非黑色素瘤皮肤癌是皮肤恶性肿瘤,代表美国最常见的癌症形式。它们主要由基底细胞癌和鳞状细胞癌(cSCC)组成。cSCC的发病率正在增加,导致相当大的发病率和越来越高的治疗费用;目前每年超过10亿美元。在这里,我们回顾了定义cSCC的分子基础和发展的研究,旨在为发病机制提供新的见解,并推动新的,节省成本和发病率的治疗方法的发展。
Non-melanoma skin cancers are cutaneous malignancies representing the most common form of cancer in the United States. They are comprised predominantly of basal cell carcinomas and squamous cell carcinomas (cSCC). The incidence of cSCC is increasing, resulting in substantial morbidity and ever higher treatment costs; currently in excess of one billion dollars, per annum. Here, we review research defining the molecular basis and development of cSCC that aims to provide new insights into pathogenesis and drive the development of novel, cost and morbidity saving therapies.
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