Scuba diving enhances endogenous antioxidant defenses in lymphocytes and neutrophils
Scuba diving enhances endogenous antioxidant defenses in lymphocytes and neutrophils
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DOI：
10.1080/10715760601080371
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发表时间：
2007-01-01
影响因子：
3.3
通讯作者：
Pons, A.
中科院分区：
文献类型：
--
作者：
Ferrer, M. D.;Sureda, A.;Pons, A.
目的是研究水肺潜水对淋巴细胞抗氧化系统，NO合成，产生活性氧的能力和中性粒细胞的抗氧化反应的影响。为此目的，7名男性潜水员进行了浸泡在40米的深度为25分钟。相同的参数进行测量后，高压氧（HBO）治疗在休息条件下，在高压舱。淋巴细胞H2 O2产生上升后潜水和HBO治疗。淋巴细胞谷胱甘肽过氧化物酶（GPx）和过氧化氢酶活性潜水后增加，而HBO暴露后，只有GPx活性增加。淋巴细胞HO-1 mRNA表达在潜水后和HBO暴露后增加，而iNOS水平和亚硝酸盐水平在潜水后显著增加。与水肺潜水相关的高氧导致氧化应激的条件，增加淋巴细胞H2 O2产生，HO-1表达，NO合成和抗氧化酶适应，以避免氧化损伤。
The aim was to study the effects of a scuba diving session on the lymphocyte antioxidant system, NO synthesis, the capability to produce reactive oxygen species and the antioxidant response in neutrophils. For that purpose seven male divers performed an immersion at a depth of 40 m for 25 min. The same parameters were measured after an hyperbaric oxygen (HBO) treatment at resting conditions in a hyperbaric chamber. Lymphocyte H2O2 production rose after diving and after HBO treatment. Glutathione peroxidase (GPx) and catalase activities increased after diving in lymphocytes, while after HBO exposure only increased GPx activity. Lymphocyte HO-1 mRNA expression increased after diving and after HBO exposure, while iNOS levels and nitrite levels significantly increased after diving. The hyperoxia associated to scuba diving leads to a condition of oxidative stress with increased lymphocyte H2O2 production, HO-1 expression, NO synthesis and antioxidant enzyme adaptations in order to avoid oxidative damage.