The Centrality of S-Adenosylhomocysteinase in the Regulation of the Biological Utilization of S-Adenosylmethionine
The Centrality of S-Adenosylhomocysteinase in the Regulation of the Biological Utilization of S-Adenosylmethionine
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S-腺苷高半胱氨酸酶在调节 S-腺苷甲硫氨酸的生物利用中的中心地位
DOI：
10.1007/978-1-4612-5012-8_19
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发表时间：
1986
期刊：
影响因子：
7.8
通讯作者：
G. Cantoni
中科院分区：
文献类型：
--
作者：
G. Cantoni
s -腺苷型同型半胱氨酸（AdoHcy）最初是作为s -腺苷型蛋氨酸（AdoMet）的转甲基化反应的产物之一分离出来的（Cantoni & Scarano, 1954），已被证明是所有甲基转移酶的竞争性抑制剂。Gibson等人（1961）首先在磷脂酰乙醇胺甲基转移酶上证明了这一点，后来扩展到其他甲基转移酶（Borchardt, 1977）。特别有趣的是，adhcy在AdoMet参与的大多数反应中都是竞争性抑制剂，无论是作为甲基或烷基给体的反应，还是作为变构效应体的反应。
S-Adenosylhomocysteine (AdoHcy), first isolated as one of the products of transmethylation reactions from S-adenosylmethionine (AdoMet) (Cantoni & Scarano, 1954) has been shown to be a competitive inhibitor of all methyltransferases. This was first shown by Gibson et al. (1961) for phosphatidylethanolamine methyltransferase and later extended to other methyltransferases (Borchardt, 1977). Of special interest is the fact that AdoHcy is a competitive inhibitor of most of the reactions in which AdoMet participates, both those where it serves as a methyl or an alkyl donor, and those where it functions as an allosteric effector.
DOI：
10.1016/s0021-9258(17)43053-5
发表时间：
1984-04
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
R. Borchardt;B. Keller;U. Patel-Thombre
通讯作者：
R. Borchardt;B. Keller;U. Patel-Thombre
影响因子：
2.9
作者：
U. Patel-Thombre;R. Borchardt
通讯作者：
U. Patel-Thombre;R. Borchardt
2-脱氧腺苷灭活S-腺苷高半胱氨酸酶的机制。
DOI：
10.1016/0006-291x(80)90829-3
发表时间：
1980
影响因子：
3.1
作者：
Abeles,RH;TashjianJr,AH;Fish,S
通讯作者：
Fish,S