Higher C-Reactive Protein and Soluble Tumor Necrosis Factor Receptor Levels Are Associated With Poor Physical Function and Disability: A Cross-Sectional Analysis of a Cohort of Late Middle-Aged African Americans
Higher C-Reactive Protein and Soluble Tumor Necrosis Factor Receptor Levels Are Associated With Poor Physical Function and Disability: A Cross-Sectional Analysis of a Cohort of Late Middle-Aged African Americans
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DOI：
10.1093/gerona/glp148
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发表时间：
2010-03-01
影响因子：
5.1
通讯作者：
Morley, John E.
中科院分区：
文献类型：
--
作者：
Haren, Matthew T.;Malmstrom, Theodore K.;Morley, John E.
背景。这群“中年晚期”的非裔美国人残疾严重。我们的目的是确定循环细胞因子受体（sTNFR1, sTNFR2）的相关性。sIL-6R)和c反应蛋白（CRP）与残疾、身体功能和身体成分的关系。密苏里州圣路易斯市两个不同社会经济阶层的分层抽样。发生在2000-2001年。纳入标准为自我报告的黑人或非裔美国人种族，包括1936-1950年出生，最低精神状态检查分数为16分或更高。在家评估握力，瘦体重百分比（LBM%）。身体机能、上半身和下半身功能限制（ubfl和lbfl）以及日常生活基本活动和辅助活动（BADLs和IADLs）。在998名参与者中，有368人在基线时采血。血清于2006年保存并检测。lbfl2及以上的绝对风险为46%；ufl为1或以上。23.5%;badl为2或以上，20.6%；iadl大于等于2，占22.5%。独立于年龄、性别、和潜在的并存状况,高c反应蛋白和sTNFR与贫穷有关物理性能(β= -1.462,p <措施和β= -0.618,p = .003), UBFLs(比值比(或)2.26,95%可信区间[CI] 1.1 - -4.64或1.39,95% CI 0.96 - -2.02), LBFLs(或2.30,95%可信区间1.19 - -4.45或1.91,95% CI 1.26 - -2.91), BADLs(或2.79,95%可信区间1.03 - -5.96或1.66,95% CI 1.11 - -2.46),和IADLs(或2.13,95%可信区间1.03 - -4.41或1.43,95% CI 0.99 - -2.08)。较高的CRP （β = -3.251, p < 0.001）、sIL-6R （β = -6.152, p = 0.013）和较低的脂联素（β = 2.947, p = 0.052）与较低的LBM%相关。较高的CRP和sTNFR与残疾和身体功能障碍独立相关。较高的sIL-6R、CRP和较低的脂联素与较低的LBM%相关。
Background. This cohort of "late middle-aged" African Americans has all excess of disability. We aimed to determine associations of circulating cytokine receptors (sTNFR1, sTNFR2. and sIL-6R) and C-reactive protein (CRP) with disability, physical function, and body composition.Methods. Stratified sampling of two socioeconomically diverse strata of St Louis, Missouri. occurred in 2000-2001. Inclusion criteria were self-reported black or African American race, born 1936-1950 inclusive, and Mini-Mental State Examination score of 16 or greater. In-home evaluations of handgrip strength, lean body mass percentage (LBM%). physical performance, upper and lower body functional limitations (UBFLs and LBFLs), and basic and instrumental activities of daily living (BADLs and IADLs) were collected. Of the 998 participants, 368 had blood sampled at baseline. Serum was stored and assayed in 2006.Results. Absolute risks were LBFLs of 2 or more, 46%; UBFLs of I or more. 23.5%; BADLs of 2 or more, 20.6%; and IADLs of 2 or more, 22.5%. Independent of age, sex, and underlying comorbid conditions, higher CRP and sTNFR were associated with poorer physical performance (beta = -1.462, p < .001 and beta = -0.618, p =.003), UBFLs (odds ratio [OR] 2.26, 95% confidence interval [CI] 1.1-4.64 and OR 1.39, 95% CI 0.96-2.02), LBFLs (OR 2.30, 95% CI 1.19-4.45 and OR 1.91, 95% CI 1.26-2.91), BADLs (OR 2.79, 95% CI 1.03-5.96 and OR 1.66, 95% CI 1.11-2.46), and IADLs (OR 2.13, 95% CI 1.03-4.41 and OR 1.43, 95% CI 0.99-2.08). Higher CRP (beta = -3.251, p < .001) sIL-6R (beta = -6.152, p = .013), and lower adiponectin (beta = 2.947, p = .052) were associated with lower LBM%.Conclusions. Higher CRP and sTNFR are independently associated with disability and physical dysfunction. Higher sIL-6R, CRP, and lower adiponectin associate with lower LBM%.