PH-RESPONSIVE LIPOSOMES WHICH CONTAIN AMPHIPHILES PREPARED BY USING LIPOPHILIC RADICAL INITIATOR
PH-RESPONSIVE LIPOSOMES WHICH CONTAIN AMPHIPHILES PREPARED BY USING LIPOPHILIC RADICAL INITIATOR
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DOI：
10.1021/ma00001a007
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发表时间：
1991-01-07
期刊：
影响因子：
5.5
通讯作者：
ISE, N
中科院分区：
文献类型：
--
作者：
KITANO, H;AKATSUKA, Y;ISE, N
合成了一种含两个N，N-双十八烷基酰胺基团的亲脂性偶氮自由基引发剂，并利用该引发剂进行了丙烯酸的齐聚反应。所得两亲物与二棕榈酰磷脂酰胆碱（DPPC）形成稳定的脂质体，并且脂质体显示荧光团曙红Y从脂质体的内部水池到体相的pH响应性释放。考察了寡聚化程度、脂质体含量、盐浓度和温度对pH敏感性的影响。总之，两亲物可用作pH响应装置的组分。
A lipophilic azo radical initiator having two N,N-dioctadecylamide groups was prepared, and oligomerization of acrylic, acid was carried out by using the initiator. The amphiphiles obtained formed a stable liposome with dipalmitoylphosphatidylcholine (DPPC), and the liposome showed a pH-responsive release of fluorophore, Eosin Y, from an inner water pool of the liposome to the bulk phase. Effects of the degree of oligomerization, content of the liposome, salt concentration, and temperature on the pH sensitivity were examined. In conclusion, the amphiphiles can be used as a component of a pH-responsive device.