Prevalence of cerebrovascular lesions in Parkinson's disease. A postmortem study
Prevalence of cerebrovascular lesions in Parkinson's disease. A postmortem study
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DOI：
10.1007/s00401-003-0676-3
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发表时间：
2003-05-01
影响因子：
12.7
通讯作者：
Jellinger, KA
中科院分区：
文献类型：
--
作者：
Jellinger, KA
关于帕金森病（PD）和中风之间关系的数据一直相互矛盾，一些研究表明生活中中风的风险降低，另一些研究表明中风相关死亡的风险增加。采用常规和免疫组化方法对尸检证实的特发性PD（脑干型路易体病）和年龄匹配的对照组（n=535）进行比较。帕金森病患者脑血管病变（腔隙、淀粉样血管病、白色病变、陈旧性和近期缺血性梗死和脑梗死）的总频率（44.0%）高于对照组（32.8%），而帕金森病患者中急性、通常致命的缺血性或出血性卒中的频率较低（1.8% vs 2.6%）。像以前在一个较小的队列中的尸检结果一样，这些结果既没有表明对中风的保护作用，也没有表明研究人群中中风死亡的易感性更高。除了严重脑血管病变的病例外，PD患者的认知功能障碍似乎在很大程度上独立于并存的血管病变。
Data on the relationship between Parkinson's disease (PD) and stroke have been conflicting, some studies showing a reduced risk of stroke during life, and others indicating an increased risk of stroke-related death. Consecutive cases (n=617) of autopsy-proven idiopathic PD (Lewy body disease of the brain stem type) and age-matched controls (n=535) were compared using current routine and immunohistochemical methods. The total frequency of cerebrovascular lesions (lacunes, amyloid angiopathy, white matter lesions, old and recent ischemic infarcts and hemorrhages) in PD (44.0%) was higher than in controls (32.8%), while acute, often fatal ischemic or hemorrhagic strokes were less frequent in parkinsonian patients (1.8% vs 2.6%). Like previous postmortem findings in a smaller cohort, these findings neither indicate a protective effect against stroke nor a greater susceptibility to death from stroke in the populations studied. Cognitive impairment in PD appears to be largely independent from coexistent vascular pathology except in cases with severe cerebrovascular lesions.