Detection of knee synovitis using non-contrast-enhanced qDESS compared with contrast-enhanced MRI.
Detection of knee synovitis using non-contrast-enhanced qDESS compared with contrast-enhanced MRI.
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DOI：
10.1186/s13075-021-02436-8
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发表时间：
2021-02-13
影响因子：
4.9
通讯作者：
Oei EHG
中科院分区：
文献类型：
--
作者：
de Vries BA;Breda SJ;Sveinsson B;McWalter EJ;Meuffels DE;Krestin GP;Hargreaves BA;Gold GE;Oei EHG
评估定量双回波稳态（qDESS）MRI检测膝关节骨关节炎（OA）滑膜炎的诊断准确性。前瞻性纳入不同程度影像学膝关节OA患者。所有患者均接受了qDESS和对比增强T1加权磁共振成像（CE-MRI）的MRI检查。两个qDESS图像的线性组合可用于创建显示滑膜和滑液之间的对比度的图像。使用全膝关节滑膜炎总分半定量评估qDESS和CE-MRI上的滑膜炎，表明无/不确定、轻度、中度和重度滑膜炎。使用斯皮尔曼等级相关系数和绝对一致性的组内相关系数确定qDESS和CE-MRI（参考标准）总分之间的相关性。以CE-MRI为参考标准，进行受试者操作特征分析，以评估qDESS检测不同程度滑膜炎的诊断性能。在纳入的31例患者中，qDESS和CE-MRI上的滑膜炎总分之间存在非常强的相关性（ρ = 0.96，p < 0.001），绝对一致性高（0.84（95%CI 0.14-0.95））。qDESS 5.16（3.75）的平均总分（SD）值低于CE-MRI 7.13（4.66），表明qDESS系统性低估了滑膜炎的严重程度。对于轻度或更严重的滑膜炎，qDESS的敏感性和特异性较高（分别为1.00（95%CI 0.80-1.00）和0.909（0.571-1.00））。对于检测中度或更高程度的滑膜炎，敏感性和特异性良好（分别为0.727（95%CI 0.393-0.927）和1.00（0.800-1.00））。qDESS MRI能够检测膝关节OA患者的滑膜炎，但存在低估。
To assess diagnostic accuracy of quantitative double-echo in steady-state (qDESS) MRI for detecting synovitis in knee osteoarthritis (OA). Patients with different degrees of radiographic knee OA were included prospectively. All underwent MRI with both qDESS and contrast-enhanced T1-weighted magnetic resonance imaging (CE-MRI). A linear combination of the two qDESS images can be used to create an image that displays contrast between synovium and the synovial fluid. Synovitis on both qDESS and CE-MRI was assessed semi-quantitatively, using a whole-knee synovitis sum score, indicating no/equivocal, mild, moderate, and severe synovitis. The correlation between sum scores of qDESS and CE-MRI (reference standard) was determined using Spearman’s rank correlation coefficient and intraclass correlation coefficient for absolute agreement. Receiver operating characteristic analysis was performed to assess the diagnostic performance of qDESS for detecting different degrees of synovitis, with CE-MRI as reference standard. In the 31 patients included, very strong correlation was found between synovitis sum scores on qDESS and CE-MRI (ρ = 0.96, p < 0.001), with high absolute agreement (0.84 (95%CI 0.14–0.95)). Mean sum score (SD) values on qDESS 5.16 (3.75) were lower than on CE-MRI 7.13 (4.66), indicating systematically underestimated synovitis severity on qDESS. For detecting mild synovitis or higher, high sensitivity and specificity were found for qDESS (1.00 (95%CI 0.80–1.00) and 0.909 (0.571–1.00), respectively). For detecting moderate synovitis or higher, sensitivity and specificity were good (0.727 (95%CI 0.393–0.927) and 1.00 (0.800–1.00), respectively). qDESS MRI is able to, however with an underestimation, detect synovitis in patients with knee OA.
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影响因子：
27.4
作者：
Atukorala I;Kwoh CK;Guermazi A;Roemer FW;Boudreau RM;Hannon MJ;Hunter DJ
通讯作者：
Hunter DJ
影响因子：
13.3
作者：
de Lange-Brokaar, B. J. E.;Ioan-Facsinay, A.;Kloppenburg, M.
通讯作者：
Kloppenburg, M.
影响因子：
5
作者：
Gold, GE;Han, E;Beaulieu, C
通讯作者：
Beaulieu, C
影响因子：
3.3
作者：
Bieri, Oliver;Ganter, Carl;Scheffler, Klaus
通讯作者：
Scheffler, Klaus
影响因子：
19.7
作者：
Yoo, Hye Jin;Hong, Sung Hwan;Kang, Heung Sik
通讯作者：
Kang, Heung Sik