Genetic characterization of bank vole virus (BaVV), a new paramyxovirus isolated from kidneys of bank voles in Russia
Genetic characterization of bank vole virus (BaVV), a new paramyxovirus isolated from kidneys of bank voles in Russia
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DOI：
10.1007/s00705-017-3639-z
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发表时间：
2018-03-01
影响因子：
2.7
通讯作者：
Shchetinin, Alexey
中科院分区：
文献类型：
--
作者：
Alkhovsky, Sergey;Butenko, Alexander;Shchetinin, Alexey
对1973年从俄罗斯银鼠（Myodes glareolus）肾组织中分离的银鼠病毒（BaVV）进行了全基因组测序。BaVV（3 ′-N-P/V/C-M-F-G-L-5 ′，长度为16，992 nt; GenBank登录号MF 943130）的基因组结构与莫斯曼病毒（MoV）和纳里瓦病毒（NarPV）的基因组结构最相似，这两种病毒是分别从澳大利亚和特立尼达的啮齿动物中分离的两种未分组的副粘病毒。BaVV的蛋白质与MoV和NarPV的蛋白质具有最高水平的序列同一性（范围从G蛋白的23-28%到M蛋白的66-73%）。遗传和系统发育分析的结果表明，BaVV代表一个新的物种，与MoV和NarPV，属于一个新的，但尚未建立的属的家庭副粘病毒。
A genome of bank vole virus (BaVV), isolated from kidney tissues of bank voles (Myodes glareolus) in Russia in 1973, was sequenced. The genomic organization of BaVV (3'-N-P/V/C-M-F-G-L-5', 16,992 nt in length; GenBank accession number MF943130) is most similar to that of Mossman virus (MoV) and Nariva virus (NarPV), two ungrouped paramyxoviruses isolated from rodents in Australia and Trinidad, respectively. The proteins of BaVV have the highest level of sequence identity (ranging from 23-28% for G protein to 66-73% for M protein) to proteins of MoV and NarPV. The results of genetic and phylogenetic analysis suggest that BaVV represents a new species and, together with MoV and NarPV, belongs to a new, yet not established genus of the family Paramyxoviridae.