Association between metabolic abnormalities and hepatitis C-related hepatocellular carcinoma
Association between metabolic abnormalities and hepatitis C-related hepatocellular carcinoma
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DOI：
10.1016/s1665-2681(19)31462-0
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发表时间：
2012-07-01
影响因子：
3.8
通讯作者：
Sharawe, Mohammed A.
中科院分区：
文献类型：
--
作者：
Khattab, Mahmoud A.;Eslam, Mohammed;Sharawe, Mohammed A.
背景和目的。代谢综合征被认为是肝细胞癌（HCC）发展的潜在危险因素。代谢因子与丙型肝炎（HCV）相关的HCC之间的关系尚未得到很好的阐明。本研究旨在阐明代谢因子在hcv相关HCC中的作用。材料和方法。我们招募了147名HCC患者，并将其与147名匹配的CHC患者和320名对照进行比较。评估所有参与者的血浆稳态模型评估- ir （HOMA-IR）、脂联素和脂质水平。结果。与匹配的CHC患者和对照组相比，HCC组的胰岛素、葡萄糖、HOMA-IR和脂联素水平显著升高，总胆固醇、HDL-C、LDL-C和甘油三酯水平显著降低。HOMA-IR与HCC的病理特征无关，而血清脂联素水平与肿瘤结节的大小呈正相关（P = 0.009）。基于逐步logistic回归分析，年龄（OR: 1.456, 95% CI: 1.072-1.979, P < 0.01）、HOMA-IR （OR: 2.50, 95% CI: 1.70-3.69, P = 0.001）和脂联素（OR: 1.585, 95% CI: 1.269-1.980, P = 0.001）与HCC独立相关。结论。代谢异常与hcv相关性HCC的发生发展密切相关。CHC和血清脂联素水平高的患者患肝癌的风险更高。HOMA-IR测量的胰岛素抵抗与hcv相关的HCC显著相关。
Background and aim. Metabolic syndrome is recognised as a potential risk factor for the development of hepatocellular carcinoma (HCC). The association between metabolic factors and hepatitis C (HCV)-related HCC has not yet been well clarified. This study was conducted to elucidate the role of metabolic factors in HCV-related HCC. Material and methods. We recruited 147 HCC patients and compared them with 147 matched CHC patients and 320 controls. The plasma levels of homeostasis model assessment-IR (HOMA-IR), adiponectin and lipids for all participants were assessed. Results. The HCC group showed significantly higher levels of insulin, glucose, HOMA-IR and adiponectin as well as lower levels of total cholesterol, HDL-C, LDL-C, and triglycerides compared with the matched CHC patients and controls. HOMA-IR did not correlate with pathologic features of HCC, whereas serum adiponectin levels correlated positively with the size of tumour nodules (P = 0.009). Based on stepwise logistic regression analysis, age (OR: 1.456, 95% CI: 1.072-1.979, P < 0.01), HOMA-IR (OR: 2.50, 95% CI: 1.70-3.69, P = 0.001), and adiponectin (OR: 1.585, 95% CI: 1.269-1.980, P = 0.001) were independently associated with HCC. Conclusions. Metabolic abnormalities are closely associated with the occurrence and development of HCV-related HCC. Patients with CHC and high serum adiponectin levels face a higher risk of developing liver cancer. Insulin resistance, as measured by HOMA-IR, is significantly associated with HCV-related HCC.