Sympathetic Nervous System and Exercise Affects Cognition in Youth (SNEACY): study protocol for a randomized crossover trial.
Sympathetic Nervous System and Exercise Affects Cognition in Youth (SNEACY): study protocol for a randomized crossover trial.
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DOI：
10.1186/s13063-021-05096-w
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发表时间：
2021-02-18
期刊：
影响因子：
2.5
通讯作者：
Hillman C
中科院分区：
文献类型：
--
作者：
Raine LB;McDonald K;Shigeta TT;Hsieh SS;Hunt J;Chiarlitti NA;Lim M;Gebhardt K;Collins N;De Lisio M;Mullen SP;Kramer AF;Hillman C
儿童时期缺乏身体活动的现象越来越普遍，这与各种健康问题有关。然而，急性运动有益于儿童认知的机制仍然未知。在这里，我们描述了一项名为SNEACY（交感神经系统和运动影响青少年认知）的随机交叉试验的方案，该研究旨在更好地了解9-10岁健康，认知正常儿童的急性运动和认知之间的联系机制。将招募来自马萨诸塞州大波士顿地区的儿童参与本单中心研究。将采用随机交叉设计，使受试者通过初始随机化条件分配和受试者之间的条件平衡作为自己的对照。103名儿童将参与三种随机急性干预：中等强度的跑步机运动（20分钟，最大心率的70-75%），坐位休息（20分钟）和特里尔儿童社会压力测试（14分钟）。这些访视将在3个不同的日期进行，大约间隔5-8天。在每次干预之前和之后，儿童完成各种认知任务，测量注意力抑制，同时记录他们的神经电活动。感兴趣的变量包括EEG数据、准确性和反应时间、学习成绩和唾液α淀粉酶。在干预后还评估了学业成绩。此外，儿童在整个干预过程中提供被动唾液样本，以测量各种生物标志物，这些生物标志物可以解释急性运动对认知的益处。这项研究的结果可能会影响教育和公共卫生建议，以提高青春期前儿童的认知和学习。ClinicalTrials.gov NCT03592238。2018年7月19日注册
There is an increasing prevalence of physical inactivity during childhood, which is associated with a variety of health problems. However, the mechanisms by which acute exercise benefits cognition in childhood remains unknown. Here we describe the protocol for a randomized crossover trial called SNEACY (Sympathetic Nervous System & Exercise Affects Cognition in Youth), a study designed to better understand mechanisms linking acute exercise and cognition in 9–10-year-old healthy, cognitively normal children. Children from the Greater Boston, MA region will be recruited to participate in this single center study. A randomized crossover design will be utilized, such that participants will act as their own controls, through initial randomization to condition assignment and condition counterbalancing across participants. One hundred three children will participate in three randomized acute interventions: moderate intensity treadmill exercise (20 min, 70–75% of their maximal heart rate), seated rest (20 min), and a Trier Social Stress Test for Children (14 min). These visits will occur on 3 three separate days, approximately 5–8 days apart. Before and after each intervention, children complete a variety of cognitive tasks measuring attentional inhibition while their neuroelectric activity is recorded. Variables of interest include EEG data, accuracy and reaction time, academic achievement, and salivary alpha amylase. Academic achievement is also assessed following interventions. In addition, children provide passive drool samples throughout the interventions to measure various biomarkers that may explain the acute exercise benefit on cognition. The results from this study could influence educational and public health recommendations to enhance cognition and learning in pre-adolescent children. ClinicalTrials.gov NCT03592238. Registered on 19 July 2018
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DOI：
10.1519/00124278-200205000-00018
发表时间：
2002-05-01
影响因子：
3.2
作者：
Jacks, DE;Sowash, J;Andres, F
通讯作者：
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影响因子：
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Drollette ES;Scudder MR;Raine LB;Moore RD;Saliba BJ;Pontifex MB;Hillman CH
通讯作者：
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DOI：
10.5005/jp-journals-10005-1227
发表时间：
2014-01
影响因子：
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作者：
Noorani H;Joshi HV;Shivaprakash P
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