The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness
The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness
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DOI：
10.1016/s0014-4827(03)00250-7
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发表时间：
2003-08-15
影响因子：
3.7
通讯作者：
Di Renzo, MF
中科院分区：
文献类型：
--
作者：
Maggiora, P;Lorenzato, A;Di Renzo, MF
罗恩是包括MET癌基因的受体酪氨酸激酶基因家族的成员，MET癌基因的种系突变与人类肿瘤发生有因果关系。在体外，罗恩和MET受体在细胞内信号传导中相互作用，协同作用，并在诱导形态发生反应中协同作用。我们发现罗恩和MET癌基因分别在55%和56%的卵巢癌中表达，在42%的卵巢癌中同时表达（P
RON is a member of the receptor tyrosine kinase gene family that includes the MET oncogene, whose germline mutations have been causally related to human tumorigenesis. In vitro, RON and MET receptors cross-talk, synergize in intracellular signaling, and cooperate in inducing morphogenic responses. Here we show that the RON and MET oncogenes were expressed in 55% and 56% of human ovarian carcinomas, respectively, and were significantly coexpressed in 42% (P