Canine parvovirus type 2c infection in a kitten associated with intracranial abscess and convulsions
Canine parvovirus type 2c infection in a kitten associated with intracranial abscess and convulsions
复制标题
DOI：
10.1016/j.jfms.2010.11.012
复制
发表时间：
2011-04-01
影响因子：
1.7
通讯作者：
Buonavoglia, Canio
中科院分区：
文献类型：
--
作者：
Decaro, Nicola;Desario, Costantina;Buonavoglia, Canio
据报道，一例 3 个月大的野猫感染犬细小病毒 2c 型 (CPV-2c)，患有脑脓肿和神经系统疾病。该猫表现出共济失调和抽搐，并伴有胃肠炎症状以及白细胞总数和分类计数的显着变化。通过 TaqMan 检测在受影响小猫的血液和粪便中检测到细小病毒株，通过分子检测将其定性为 CPV，但不与任何 CPV 类型特异性探针发生反应。通过对 VP2 蛋白基因的序列和系统发育分析，CPV-2c 菌株在探针结合区显示出非编码突变。尽管 CPV-2c 在这种特殊情况下的作用尚不清楚，但它可能使小猫容易出现所见的临床症状。需要持续监测来监测这种 CPV-2c 突变体未来在狗和猫群体中的传播以及任何相关的临床症状。 (C) 2010 ISFM 和 AAFP。由爱思唯尔有限公司出版。保留所有权利。
A case of canine parvovirus type 2c (CPV-2c) infection in a 3-month-old feral kitten with a cerebral abscess and neurological disease is reported. The cat displayed ataxia and convulsions together with signs of gastroenteritis and profound alteration of the total and differential white blood cell counts. A parvovirus strain was detected by a TaqMan assay in the blood and faeces of the affected kitten, which was characterised as CPV by means of molecular assays but did not react with any of the CPV type-specific probes. By sequence and phylogenetic analyses of the VP2-protein gene, the CPV-2c strain displayed a non-coding mutation in the probe-binding region. Although the role of CPV-2c in this particular case is unclear, it is possible that it predisposed the kitten to the clinical signs seen. Continuous surveillance is needed to monitor future spreading of this CPV-2c mutant, and any associated clinical signs, in the dog and cat population. (C) 2010 ISFM and AAFP. Published by Elsevier Ltd. All rights reserved.