Contractile Performance of the Hypertrophied Ventricle in Patients with Systemic Hypertension
Contractile Performance of the Hypertrophied Ventricle in Patients with Systemic Hypertension
复制标题
全身性高血压患者肥厚心室的收缩性能
作者：
M. Takahashi;S. Sasayama;C. Kawai;H. Kotoura
摘要
在本研究中，我们测定了10名正常受试者左心室射血分数、舒张末期容积、收缩末期容积、每搏量、肺通过时间、肺血容量和心输出量放射性核素测量的可重复性。在第1天和第3天，在休息时以及直立、次极量自行车运动期间进行首次通过放射性核素心血管造影。该组的静息心率从第1天的79±17次/分钟下降到第3天的71±14次/分钟（p<0.01）。这种生物学变异可能导致射血分数（从62±7%到59±7%，p<0.05）和心输出量（从7.7±1.9升/分钟到6.6±1.5升/分钟，p<0.02）小幅但显著下降，以及第1天和第3天之间肺通过时间增加（从5.8±1.6秒到6.2±1.3秒，p<0.05）。射血分数、心输出量和肺通过时间的平均变异性分别为4.0±3.8%、1.24±1.23升/分钟和0.65±0.64秒。在静息舒张末期容积、收缩末期容积和每搏量方面，研究之间未观察到显著差异。舒张末期容积的平均变异性为9.9±5.1毫升。在相同运动负荷下运动时心率变化较小，并且只有肺通过时间和血容量在研究之间有显著差异。运动期间射血分数、舒张末期容积、心输出量和肺通过时间的平均变异性分别为3.2±2.5%、9.8±6.2毫升、1.59±0.67升/分钟和0.25±0.25秒。如果在可比的血流动力学条件下获得，左心室功能的放射性核素测量具有高度可重复性。
SUMMARYIn this investigation we determined the reproducibility of radionuclide measurements of left ventricular ejection fraction, end-diastolic volume, end-systolic volume, stroke volume, pulmonary transit time, pulmonary blood volume and cardiac output in 10 normal subjects. First-pass radionuclide angiocardiograms were performed at rest and during upright, submaximal bicycle exercise on day 1 and day 3. The resting heart rate for the group decreased from 79 ± 17 beats/min on day 1 to 71 ± 14 beats/min on day 3 (p < 0.01). This biologic variation probably contributed to the small but significant decreases in ejection fraction (62 ± 7 to 59 ± 7%, p < 0.05) and cardiac output (7.7 ± 1.9 to 6.6 ± 1.5 l/min, p < 0.02), and the increase in pulmonary transit time (5.8 ± 1.6 to 6.2 ± 1.3 seconds, p < 0.05) between day 1 and day 3. The mean variabilities in ejection fraction, cardiac output and pulmonary transit time were 4.0 ± 3.8%, 1.24 ± 1.23 1/min and 0.65 ± 0.64 second, respectively. No significant differences between studies were observed in resting end-diastolic volume, end-systolic volume and stroke volume. The mean variability in enddiastolic volume was 9.9 ± 5.1 ml. Heart rate varied less during exercise to the same work load, and only pulmonary transit time and blood volume differed significantly between studies. During exercise the mean variabilities in ejection fraction, enddiastolic volume, cardiac output and pulmonary transit time were 3.2 ± 2.5%, 9.8 ± 6.2 ml, 1.59 ± 0.67 1/min and 0.25 ± 0.25 second, respectively. Radionuclide measurements of left ventricular function are highly reproducible if obtained under comparable hemodynamic conditions.