Abnormal red cell sodium content and efflux in Japanese patients with essential hypertension.
Abnormal red cell sodium content and efflux in Japanese patients with essential hypertension.
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日本原发性高血压患者红细胞钠含量和流出异常。
DOI：
10.1253/jcj.48.980
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
H. Fukuzaki
中科院分区：
文献类型：
--
作者：
K. Saito;Y. Furuta;H. Fukuzaki
测定了37例原发性高血压患者和25例年龄匹配的无高血压家族史的正常血压者的钠负荷/钾耗竭红细胞的钠净流出和钾净内流，同时测定了红细胞基础钠和钾含量。原发性高血压患者红细胞内钠含量显著高于血压正常者（10.9 +/- 1.4 vs 10.0 +/- 1.2 mmol/L X细胞，平均值+/- SD，p <0.02），但两组间钾含量几乎相等。高血压组与正常血压组相比，Na净流出量明显减少（4.57 ± 0.70 vs 5.18 ± 1.02 mmol/L ×细胞× h，p <0.01），而K净流入量和Na/K净流出量比值无明显差异。Na净流出量和K净流入量与红细胞钠含量呈显著负相关（分别为r = -0.64和r =-0.56，p <0.001）。结果提示，红细胞钠含量增加，钠净流出减少，可能与原发性高血压的发病有关。然而，不可能通过使用日本受试者的净Na/K通量比来确定原发性高血压的遗传标记，尽管Garay等人报告说，欧洲人的这一指数异常低。
Net sodium (Na) efflux and potassium (K) influx were determined in Na-loaded/K-depleted erythrocytes derived from 37 patients with essential hypertension and 25 age-matched normotensive subjects with no family history of hypertension, together with the measurement of basal red cell sodium and potassium contents. Intraerythrocyte sodium content was significantly higher in the essential hypertensives than in the normotensives (10.9 +/- 1.4 vs 10.0 +/- 1.2 mmol/L X cells, mean +/- SD, p less than 0.02), but potassium content was nearly equal between the two groups. Net Na efflux in the hypertensives was significantly reduced compared with that in the normotensives (4.57 +/- 0.70 vs 5.18 +/- 1.02 mmol/L X cells X hr, p less than 0.01), but both net K influx and net Na/K flux ratio were not significantly different between the two groups. Net Na efflux and K influx showed a significant inverse correlation with red cell sodium content (r = -0.64 and r = -0.56, respectively, p less than 0.001). These results suggest that the reduced net Na efflux with the increase of red cell sodium content may be related to the pathogenesis of essential hypertension. However, it is impossible to determine the genetic marker of essential hypertension by using the net Na/K flux ratio of Japanese subjects, although Garay et al. have reported that this index was abnormally low in the case of Europeans.