Prenatal Adversity Modulates the Quality of Maternal Care Via the Exposed Offspring
Prenatal Adversity Modulates the Quality of Maternal Care Via the Exposed Offspring
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DOI：
10.1002/bies.201900025
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发表时间：
2019-06-01
期刊：
影响因子：
4
通讯作者：
John, Rosalind M.
中科院分区：
文献类型：
--
作者：
John, Rosalind M.
怀孕期间的粘连，包括不良的饮食和压力，与以后生活中发展代谢和心理健康障碍的风险增加有关，这种现象被描述为胎儿编程或疾病的发育起源。解释这种关系的主要假设表明，逆境对发育中的胎儿施加了直接的变化，这些变化在出生后得到维持，导致对疾病的易感性增加。然而，在怀孕期间，母亲、发育中的胎儿和胎盘都暴露在逆境中。与后代结局改变相关的相同逆境也可能导致孕产妇护理不佳，这被认为是对后代的独立不利暴露。最近在小鼠中进行的关键实验揭示了产前逆境通过异常的母婴相互作用和胎盘信号的改变来改变孕产妇护理的潜力。总之，这些数据突出了从整体上观察胎儿编程的至关重要性，要注意母亲与子女之间的亲密，双向和互动关系。
Adversities in pregnancy, including poor diet and stress, are associated with increased risk of developing both metabolic and mental health disorders later in life, a phenomenon described as fetal programming or developmental origins of disease. Predominant hypotheses proposed to explain this relationship suggest that the adversity imposes direct changes to the developing fetus which are maintained after birth resulting in an increased susceptibility to ill health. However, during pregnancy the mother, the developing fetus, and the placenta are all exposed to the adversity. The same adversities linked to altered offspring outcome can also result in suboptimal maternal care, which is considered an independent adverse exposure for the offspring. Recent key experiments in mice reveal the potential of prenatal adversity to drive alterations in maternal care through abnormal maternal-pup interactions and via alterations in placental signaling. Together, these data highlight the critical importance of viewing fetal programming holistically paying attention to the intimate, bidirectional, and reiterative relationship between mothers and their offspring.