Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability.
Increased Risk of Nonalcoholic Fatty Liver Disease in Individuals with High Weight Variability.
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DOI：
10.3803/enm.2021.1098
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发表时间：
2021-08
期刊：
影响因子：
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通讯作者：
Lee WY
中科院分区：
文献类型：
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作者：
Jung I;Koo DJ;Lee MY;Moon SJ;Kwon H;Park SE;Rhee EJ;Lee WY
建议非酒精性脂肪肝 (NAFLD) 患者通过改变生活方式来减肥。最近的研究表明，体重反复减轻和增加与健康状况恶化有关。本研究旨在探讨非糖尿病患者体重变异性与 NAFLD 风险之间的关联。我们检查了 2010 年至 2014 年间进行过系列检查的 30,708 名参与者的健康检查数据。体重变异性是使用变异系数和平均体重连续变异性 (ASVW) 来评估的，ASVW 定义为 5 年期间连续几年之间的绝对体重变化之和除以 4。根据基线体重指数和 4 年内的体重差异对参与者进行分类。根据 ASVW 四分位组将参与者分为四组，与最低四分位的参与者相比，最高四分位的参与者患 NAFLD 的风险显着增加（比值比 [OR]，1.89；95% 置信区间 [CI]，1.63 至 2.19）。在基线时没有肥胖的参与者中，ASVW 高的个体患 NAFLD 的风险增加（OR，1.80；95% CI，1.61 至 2.01）。与体重稳定和低 ASVW 的参与者相比，体重超过 4 年增加且 ASVW 高的参与者表现出更高的 NAFLD 风险（OR，4.87；95% CI，4.29 至 5.53）。无论参与者的基线肥胖状况如何，高体重变异性都与患 NAFLD 的风险增加相关。我们的结果表明，在达到理想体重后，需要进一步努力以尽量减少体重波动。
Weight loss through lifestyle modification is recommended for patients with nonalcoholic fatty liver disease (NAFLD). Recent studies have suggested that repeated loss and gain of weight is associated with worse health outcomes. This study aimed to examine the association between weight variability and the risk of NAFLD in patients without diabetes. We examined the health-checkup data of 30,708 participants who had undergone serial examinations between 2010 and 2014. Weight variability was assessed using coefficient of variation and the average successive variability of weight (ASVW), which was defined as the sum of absolute weight changes between successive years over the 5-year period divided by 4. The participants were classified according to the baseline body mass index and weight difference over 4 years. On dividing the participants into four groups according to ASVW quartile groups, those in the highest quartile showed a significantly increased risk of NAFLD compared to those in the lowest quartile (odds ratio [OR], 1.89; 95% confidence interval [CI], 1.63 to 2.19). Among participants without obesity at baseline, individuals with high ASVW showed increased risk of NAFLD (OR, 1.80; 95% CI, 1.61 to 2.01). Participants with increased weight over 4 years and high ASVW demonstrated higher risk of NAFLD compared to those with stable weight and low ASVW (OR, 4.87; 95% CI, 4.29 to 5.53). Regardless of participant baseline obesity status, high weight variability was associated with an increased risk of developing NAFLD. Our results suggest that further effort is required to minimize weight fluctuations after achieving a desirable body weight.