Thioporidiols A and B: Two New Sulfur Compounds Discovered by Molybdenum-Catalyzed Oxidation Screening from Trichoderma polypori FKI-7382
Thioporidiols A and B: Two New Sulfur Compounds Discovered by Molybdenum-Catalyzed Oxidation Screening from Trichoderma polypori FKI-7382
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DOI：
10.3390/antibiotics9050236
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发表时间：
2020-05-01
影响因子：
4.8
通讯作者：
Nakashima, Takuji
中科院分区：
文献类型：
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作者：
Matsuo, Hirotaka;Noguchi, Yoshihiko;Nakashima, Takuji
从多孔木霉FKI-7382的发酵液中发现了两个新的含硫化合物，命名为硫代泊里二醇A（1）和B（2）。1和2的结构被确定为具有N-乙酰半胱氨酸部分的C13脂质结构。1的C-5和C-6位的相对构型由α-甲氧基-α-苯乙酸二酯的衍生物确定，N-乙酰半胱氨酸部分的绝对构型由先进的马氏分析确定。评价化合物1和2的抗微生物、细胞毒性和抗疟疾活性。化合物2对白色念珠菌ATCC 64548表现出抗微生物活性。
Two new sulfur compounds, designated thioporidiol A (1) and B (2), were discovered by the MoS-screening program from a culture broth of Trichoderma polypori FKI-7382. The structures of 1 and 2 were determined as C13 lipid structures with an N-acetylcysteine moiety. The relative configuration at the C-5 and C-6 position of 1 was determined by the derivatives of alpha-methoxy-alpha-phenylacetic acid diesters, and the absolute configuration of the N-acetylcysteine moiety was determined by advanced Marfey's analysis. Compounds 1 and 2 were evaluated for anti-microbial, cytotoxic and anti-malarial activities. Compound 2 exhibited anti-microbial activity against Candida albicans ATCC 64548.