Selective bystander proliferation of memory CD4+ and CD8+ T cells upon NK T or T cell activation
Selective bystander proliferation of memory CD4+ and CD8+ T cells upon NK T or T cell activation
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DOI：
10.4049/jimmunol.165.8.4305
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发表时间：
2000-10-15
影响因子：
4.4
通讯作者：
MacDonald, HR
中科院分区：
文献类型：
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作者：
Eberl, G;Brawand, P;MacDonald, HR
Ag-经历的或记忆T细胞对回忆Ag具有增加的反应性，并且可以通过改变表面标志物如CD 44的表达而与初始T细胞区分开。记忆T细胞具有高周转率，并且在IFN-α β和/或IL-15存在下，CD 8（+）记忆T细胞在病毒感染后增殖。在这项研究中，我们通过显示活化的NKT细胞和超抗原活化的T细胞诱导CD 8（+）和CD 4（+）记忆T细胞的广泛旁观者增殖来扩展这些发现。此外，记忆T细胞的增殖可以通过IFN-α β非依赖性但IFN-γ或IL-12依赖性途径诱导。在这些旁观者激活的条件下，增殖的记忆（CD 44（高））T细胞不是源自初始（CD 44（低））T细胞的激活，而是源自真正的记忆CD 44（高）T细胞。总之，这些数据表明，不同的途径可以诱导记忆T细胞的旁观者增殖。
Ag-experienced or memory T cells have increased reactivity to recall Ag, and can be distinguished from naive T cells by altered expression of surface markers such as CD44, Memory T cells have a high turnover rate, and CD8(+) memory T cells proliferate upon viral infection, in the presence of IFN-alpha beta and/or IL-15. In this study, we extend these findings by showing that activated NKT cells and superantigen-activated T cells induce extensive bystander proliferation of both CD8(+) and CD4(+) memory T cells. Moreover, proliferation of memory T cells can be induced by an IFN-alpha beta-independent but IFN-gamma- or IL-12-dependent pathway. In these conditions of bystander activation, proliferating memory (CD44(high)) T cells do not derive from activation of naive (CD44(low)) T cells, but rather from bona fide memory CD44(high) T cells. Together, these data demonstrate that distinct pathways can induce bystander proliferation of memory T cells.