Simultaneous Determination of Di(2‐ethylhexyl)phthalate, Mono(2‐ethylhexyl)phthalate, and Phthalic Acid Migrating from Gamma‐Ray Irradiated Polyvinyl Chloride Sheet by Liquid Chromatography‐Tandem Mass Spectrometry
Simultaneous Determination of Di(2‐ethylhexyl)phthalate, Mono(2‐ethylhexyl)phthalate, and Phthalic Acid Migrating from Gamma‐Ray Irradiated Polyvinyl Chloride Sheet by Liquid Chromatography‐Tandem Mass Spectrometry
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液相色谱-串联质谱法同时测定伽马射线辐照聚氯乙烯片中的邻苯二甲酸二(2-乙基己基)酯、邻苯二甲酸单(2-乙基己基)酯和邻苯二甲酸
DOI：
10.1080/10826070701738811
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发表时间：
2007
影响因子：
1.3
通讯作者：
H. Nakazawa
中科院分区：
文献类型：
--
作者：
R. Ito;Naoko Miura;Migaku Kawaguchi;Masaru Ushiro;H. Iguchi;Yusuke Iwasaki;Koichi Saito;H. Nakazawa
摘要建立了同时测定邻苯二甲酸二(2-乙基己基)酯(DEHP)、邻苯二甲酸单(2-乙基己基)酯(MEHP)和邻苯二甲酸(PA)的LC-MS/MS方法。在该方法中，DEHP、MEHP和PA的检出限分别为5、0.5和1 ng/m L，标准溶液的定量限分别为20、2和5 ng/m L。日内和日间测定均显示良好的准确性和重复性。三种萃取剂的回收率分别为98.9%~104.2%(相对标准偏差<10.3%)。针对聚氯乙烯(PVC)医疗器械中易洗脱DEHP的特点，对辐照后的PVC片材中的DEHP及其击穿产物进行了同时测定。在辐照和对照聚氯乙烯薄膜中都观察到了DEHP的迁移。与对照聚氯乙烯片材的迁移相比，MEHP在辐照后的聚氯乙烯片材上有明显的迁移。相反，PA只从伽马射线辐照的聚氯乙烯板材中迁移。
Abstract The aim of the present study was to establish a liquid chromatography‐tandem mass spectrometric (LC‐MS/MS) method for the simultaneous determination of di(2‐ethylhexyl) phthalate (DEHP), mono(2‐ethylhexyl)phthalate (MEHP), and phthalic acid (PA). In the proposed method, the limits of detection of DEHP, MEHP, and PA were 5, 0.5, and 1 ng/mL, respectively, and the limits of quantification with standard solutions were 20, 2, and 5 ng/mL, respectively. Intra‐ and interday assays showed good accuracy and repeatability. The recoveries of DEHP, MEHP, and PA from respective extraction solvents ranged from 98.9 to 104.2% (relative standard deviation was below 10.3%). DEHP and its breakdown products migrating from gamma‐ray irradiated polyvinyl chloride (PVC) sheets were determined simultaneously since DEHP is easily eluted from PVC medical devices. DEHP migration was noted from both gamma‐ray irradiated and control PVC sheets. Compared with the migration from the control PVC sheet, MEHP showed significant migration from the gamma‐ray irradiated PVC sheet. In contrast, PA migration was noted only from the gamma‐ray irradiated PVC sheet.
影响因子：
3.8
作者：
Lovekamp, TN;Davis, BJ
通讯作者：
Davis, BJ
影响因子：
3.8
作者：
Richburg, JH;Boekelheide, K
通讯作者：
Boekelheide, K