Mortality from myocardial infarction in relation to exposure to vibration and dust among a cohort of iron-ore miners in Sweden
Mortality from myocardial infarction in relation to exposure to vibration and dust among a cohort of iron-ore miners in Sweden
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DOI：
10.1136/oem.2009.046599
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发表时间：
2010-03-01
影响因子：
4.9
通讯作者：
Nilsson, Tohr
中科院分区：
文献类型：
--
作者：
Bjor, Bodil;Burstrom, Lage;Nilsson, Tohr
本研究的目的是调查瑞典两个铁矿工人暴露于手/手臂振动（HAV）和全身振动（WBV）以及暴露于粉尘的心肌梗死（MI）死亡率。方法本研究以瑞典两家铁矿的受雇男性为研究对象，这些人在1923年至1996年间受雇至少1年。死亡原因来自1952年至2001年的全国死亡原因登记册。心肌梗死死亡率是通过将个人识别号码与国家死亡原因登记册联系起来获得的。采用泊松回归对暴露-反应关系进行风险估计，并对60岁两个年龄组进行分析。结果暴露于WBV （RR = 1.18, 95% CI = 1.06 ~ 1.31）和粉尘（RR = 1.15, 95% CI = 1.02 ~ 1.31）与暴露相关的MI死亡相对风险（0/ bb0）显著增加，表明WBV和粉尘分别存在暴露-反应关系。对于60岁及以下的人群，暴露于甲肝病毒（0/>0）（RR 1.34, 95% CI 1.03 - 1.74）和白脑病毒（0/>0）（RR 1.39, 95% CI 1.13 - 1.72）增加了心肌梗死死亡率的风险。在甲肝病毒和白脑病毒中发现了暴露反应，因为中等和高暴露类别显示出显著增加的风险估计。在60岁以上的人群中，没有任何一种暴露会显著增加患病风险。在调整粉尘暴露后，WBV暴露的风险估计值仍然增加。结论工作年龄(
Objectives The aim of this study was to investigate myocardial infarction (MI) mortality in relation to exposure to hand/arm vibration (HAV) and whole body vibration (WBV) as well as exposure to dust among men employed in two Swedish iron-ore mines.Methods This study comprised employed men at two iron-ore mines in Sweden who had been employed for at least 1 year from 1923 up to 1996. The causes of death were obtained from the national cause of death register from 1952 to 2001. Myocardial infarction mortality was obtained by linking personal identification numbers to the national cause of death register. Poisson regression was used for risk estimations on exposure-response relation, and analyses were made on the two age groups 60 years.Results Relative risks for MI mortality in relation to exposure were significantly increased for exposure (0/>0) to WBV (RR 1.18, 95% CI 1.06 to 1.31) and dust (RR 1.15, 95% CI 1.02 to 1.31), and the results indicated an exposure-response relation for WBV and dust separately. For 60 years and younger, exposure to HAV (0/>0) (RR 1.34, 95% CI 1.03 to 1.74) and WBV (0/>0) (RR 1.39, 95% CI 1.13 to 1.72) increased the risk of MI mortality. An exposure-response was found for HAV and WBV, as the medium and high exposed categories showed significantly increased risk estimates. None of the exposures significantly increased the risk in the group above 60 years. The increased risk estimates for exposure to WBV remained when adjusting for exposure to dust.Conclusions The results for the working age (