Synthetic and Degradative Investigations of the Structure of Folinic Acid-SF
Synthetic and Degradative Investigations of the Structure of Folinic Acid-SF
复制标题
亚叶酸-SF结构的合成和降解研究
DOI：
10.1021/ja01151a028
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发表时间：
1951
影响因子：
15
通讯作者：
W. Shive
中科院分区：
文献类型：
--
作者：
M. May;T. Bardos;Frank L. Barger;Myra W. Lansford;J. Ravel;G. Sutherland;W. Shive
根据合成的叶酸基团的结构，研究了由叶酸合成叶酸SF的机理，以及将叶酸SF降解为叶酸的机理。叶酸-SF在相对温和的条件下很容易被降解为叶酸，类似于从肝脏中分离叶酸的条件。据报道，一组被称为叶酸基团的因子在防止x-甲基叶酸对干酪乳杆菌3的毒性和促进柠檬酸明串珠菌8081.4生长方面比叶酸更有效。最近通过叶酸基团成员的甲酰化反应制备了几个叶酸基团的成员
Mechanisms of synthesis of folinic acid-SF from folic acid and a mechanism of degradation of folinic acid-SFto folic acid have been investigatedwith regard to the structure of this synthetic member of the folinic acid group. Folinic acid-SF is readily degraded to folic acid under relatively mild conditions similar to those used in theisolation of folic acid from liver.A group of factors, termed the folinic acid group, has been reported to be more effective than folic acid in preventing the toxicity of x-methylfolic acid for Lactobacillus casei3 and in promoting the growth of Leuconostoc citrovorum 8081.4 ab Several members of the folinic acid group have been prepared recently by formylation of members of the