Comparison of Cardiovascular Complications in Patients with and without KCNJ5 Gene Mutations Harboring Aldosterone-producing Adenomas
Comparison of Cardiovascular Complications in Patients with and without KCNJ5 Gene Mutations Harboring Aldosterone-producing Adenomas
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DOI：
10.5551/jat.24455
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发表时间：
2015-01-01
影响因子：
4.4
通讯作者：
Nishikawa, Tetsuo
中科院分区：
文献类型：
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作者：
Kitamoto, Takumi;Suematsu, Sachiko;Nishikawa, Tetsuo
目的：我们的目的是评估具有和不具有 KCNJ5 基因突变的醛固酮腺瘤 (APA) 患者在单侧肾上腺切除术前后心血管并发症的发生率。 方法：本研究共评估了 108 例 APA 患者。我们在排除 5 例 ATPase 或 CACNA1D 基因突变的 APA 患者后，根据携带或不携带 KCNJ5 基因突变的 APA 患者的心血管并发症，比较其临床特征和实验室检查结果。结果：分别有 75 例和 28 例 APA 患者存在 KCNJ5 体细胞突变（p.G151R、p.L168R、p.E145Q、p.T158A 或 157del），无突变。分别。所有受试者均未出现双重突变。 KCNJ5 突变组和野生型组在手术前表现出相似的左心室肥厚进展，尽管突变组比野生型组明显更年轻，血浆和尿液醛固酮水平更高（48.2 岁 vs. 55.8 岁）；p
Aim: Our objective was to evaluate the incidence of cardiovascular complications before and after unilateral adrenalectomy in patients with and without KCNJ5 gene mutations harboring aldosterone-producing adenoma (APA).Methods: A total of 108 APA patients were evaluated in the present study. We compared the clinical characteristics and laboratory findings according to the cardiovascular complications in the patients with or without KCNJ5 gene mutations harboring APA after excluding five APA patients with ATPase or CACNA1D gene mutations.Results: There were 75 and 28 APA patients with somatic mutations of KCNJ5 (p.G151R, p.L168R, p.E145Q, p.T158A or 157del) and no mutations, respectively. There were no double mutations in any of the subjects. The KCNJ5-mutated and wild type groups demonstrated similar advances in left ventricular hypertrophy prior to surgery, although the mutated group was significantly younger, with higher plasma and urine aldosterone levels, than the wild type group (48.2 vs. 55.8 (years old); p