ASTROCYTOSIS IN WOBBLER MOUSE SPINAL-CORD INVOLVES A POPULATION OF ASTROCYTES WHICH IS GLUTAMINE SYNTHETASE-NEGATIVE
ASTROCYTOSIS IN WOBBLER MOUSE SPINAL-CORD INVOLVES A POPULATION OF ASTROCYTES WHICH IS GLUTAMINE SYNTHETASE-NEGATIVE
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DOI：
10.1016/0304-3940(94)11145-9
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发表时间：
1995-01-09
影响因子：
2.5
通讯作者：
RIEGER, F
中科院分区：
文献类型：
--
作者：
BLONDET, B;HANTAZAMBROISE, D;RIEGER, F
受wobbler突变影响的小鼠的特征是与运动神经元变性相关的肌肉萎缩。一旦疾病的第一个临床症状出现，在脊髓灰质中观察到反应性星形胶质细胞，强烈的胶质细胞酸性蛋白（GFAP）阳性。随着疾病的进展，它们在各个层面都很普遍。谷氨酰胺合成酶（GS）的免疫染色表明，这些反应性星形胶质细胞从来没有GS阳性。摇摆脊髓中GS的活性和蛋白量保持正常，但星形细胞增多。因此，摇摆小鼠的神经胶质增生似乎涉及星形胶质细胞的亚群，这是强烈的GFAP阳性，但GS阴性。
Mice affected by the wobbler mutation are characterized by a muscular atrophy associated with motoneuron degeneration. As soon as the first clinical signs of the disease appear, reactive astrocytes, strongly glial fibrillary acidic protein (GFAP)-positive, are observed in the spinal cord grey matter. They become prevalent at all levels with disease progression. Immunostaining of glutamine synthetase (GS) shows that these reactive astrocytes are never GS-positive. The activity and protein amounts of GS remain normal in wobbler spinal cord although astrocytosis develops. Thus, gliosis in the wobbler mouse seems to involve a subpopulation of astrocytes, which is strongly GFAP-positive but GS-negative.