The Meaning, Measurement and Modification of Hypoxia in the Laboratory and the Clinic
The Meaning, Measurement and Modification of Hypoxia in the Laboratory and the Clinic
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DOI：
10.1016/j.clon.2014.02.002
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发表时间：
2014-05-01
影响因子：
3.4
通讯作者：
Williams, K. J.
中科院分区：
文献类型：
--
作者：
Hammond, E. M.;Asselin, M. -C.;Williams, K. J.
60多年前，缺氧被确定为实体瘤的微环境成分，并立即被认为是通过依赖于氧的放射治疗引起最大细胞毒性的潜在治疗障碍。在过去的二十年中，临床和实验研究都显着提高了我们对缺氧如何影响细胞行为和治疗反应的理解。此外，他们证实了早期的假设，即肿瘤中的低氧状态是癌症治疗中可利用的目标。一般来说，这种方法对缺氧肿瘤患者更有益，需要使用反映氧合状态的生物标志物。组织生物标志物已在许多研究中显示出实用性。在用正电子发射断层扫描、磁共振成像和其他成像方式非侵入性测量肿瘤缺氧方面取得了进一步的重大进展。在这里，我们描述了定义和测量肿瘤缺氧的复杂性，并强调了对抗缺氧的治疗方法。（C）2014年皇家放射科医师学院。由爱思唯尔有限公司出版。保留所有权利。
Hypoxia was identified as a microenvironmental component of solid tumours over 60 years ago and was immediately recognised as a potential barrier to therapy through the reliance of radiotherapy on oxygen to elicit maximal cytotoxicity. Over the last two decades both clinical and experimental studies have markedly enhanced our understanding of how hypoxia influences cellular behaviour and therapy response. Furthermore, they have confirmed early assumptions that low oxygenation status in tumours is an exploitable target in cancer therapy. Generally such approaches will be more beneficial to patients with hypoxic tumours, necessitating the use of biomarkers that reflect oxygenation status. Tissue biomarkers have shown utility in many studies. Further significant advances have been made in the non-invasive measurement of tumour hypoxia with positron emission tomography, magnetic resonance imaging and other imaging modalities. Here, we describe the complexities of defining and measuring tumour hypoxia and highlight the therapeutic approaches to combat it. (C) 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.