Gas-Assisted Cocrystal Desublimation
Gas-Assisted Cocrystal Desublimation
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DOI：
10.1021/acs.cgd.1c01241
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发表时间：
2022-02
影响因子：
3.8
通讯作者：
Shea Sanvordenker;Siddharth Borsadia;Steven A. Morris;N. Rodríguez-Hornedo;M. Shtein
中科院分区：
文献类型：
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作者：
Shea Sanvordenker;Siddharth Borsadia;Steven A. Morris;N. Rodríguez-Hornedo;M. Shtein
我们报告了一种新的工艺，其中药物共晶升华，通过载气传输，并以高速引导到基底上，在基底上形成纳米和微米共晶。它提供了一种“免接触”、非机械、一步式的粒径减小和共晶表面涂层方法。
We report a novel process in which pharmaceutical cocrystals are sublimed, transported by a carrier gas, and directed at high velocity at a substrate, where nano- and microscopic cocrystals are formed. It affords a “touch-free”, nonmechanical, single-step means of particle size reduction and surface coating of cocrystals.