Epithelial-Stromal Interactions in Pancreatic Cancer.
Epithelial-Stromal Interactions in Pancreatic Cancer.
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DOI：
10.1146/annurev-physiol-020518-114515
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发表时间：
2019-02
影响因子：
18.2
通讯作者：
Yaqing Zhang;H. Crawford;M. Pasca di Magliano
中科院分区：
文献类型：
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作者：
Yaqing Zhang;H. Crawford;M. Pasca di Magliano
胰腺癌的特征在于广泛的纤维炎症反应，包括免疫细胞、成纤维细胞、细胞外基质、血管和淋巴管以及神经。压倒性的证据表明，胰腺癌微环境调节癌症的发生、发展和维持。胰腺癌治疗在过去几十年中进展甚微，预后仍然是任何癌症中最差的之一。微环境对致癌作用的贡献是研究的一个关键领域，为治疗这种疾病提供了新的潜在靶点。在这里，我们探讨了胰腺癌间质的组成，讨论了不同成分之间的相互作用网络，并描述了最近尝试靶向治疗间质。我们还讨论了当前与肿瘤微环境相关的活跃研究领域。
Pancreatic cancer is characterized by an extensive fibroinflammatory reaction that includes immune cells, fibroblasts, extracellular matrix, vascular and lymphatic vessels, and nerves. Overwhelming evidence indicates that the pancreatic cancer microenvironment regulates cancer initiation, progression, and maintenance. Pancreatic cancer treatment has progressed little over the past several decades, and the prognosis remains one of the worst for any cancer. The contribution of the microenvironment to carcinogenesis is a key area of research, offering new potential targets for treating the disease. Here, we explore the composition of the pancreatic cancer stroma, discuss the network of interactions between different components, and describe recent attempts to target the stroma therapeutically. We also discuss current areas of active research related to the tumor microenvironment.