Cellular mechanosignaling for sensing and transducing matrix rigidity.
Cellular mechanosignaling for sensing and transducing matrix rigidity.
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DOI：
10.1016/j.ceb.2023.102208
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发表时间：
2023-07
影响因子：
7.5
通讯作者：
Katherine M. Young;Cynthia A. Reinhart-King
中科院分区：
文献类型：
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作者：
Katherine M. Young;Cynthia A. Reinhart-King
细胞感知其机械环境并通过粘着斑和信号传导途径将信号传递到细胞核的机制是机械生物学领域的重点关注领域。在过去的两年中，我们已经扩大了我们的知识，通常研究的途径，如雅普/TAZ，FAK/Src，RhoA/ROCK，和Piezo 1信号，以及发现新的相互作用，如细胞线粒体功能和代谢的基质刚性的影响，这代表了一个新的和令人兴奋的方向，为整个领域。这篇综述涵盖了基板刚度传感领域的最新进展以及对未来发展方向的展望。
The mechanisms by which cells sense their mechanical environment and transduce the signal through focal adhesions and signaling pathways to the nucleus is an area of key focus for the field of mechanobiology. In the past two years, there has been expansion of our knowledge of commonly studied pathways, such as YAP/TAZ, FAK/Src, RhoA/ROCK, and Piezo1 signaling, as well as the discovery of new interactions, such as the effect of matrix rigidity of cell mitochondrial function and metabolism, which represent a new and exciting direction for the field as a whole. This review covers the most recent advances in the field of substrate stiffness sensing as well as perspective on future directions.