Toward a global picture of bacterial secondary metabolism
Toward a global picture of bacterial secondary metabolism
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DOI：
10.1007/s10295-019-02136-y
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发表时间：
2019-03-01
影响因子：
3.4
通讯作者：
Seyedsayamdost, Mohammad R.
中科院分区：
文献类型：
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作者：
Seyedsayamdost, Mohammad R.
细菌代谢由初级代谢物（促进生长和增殖的细胞内生命分子）和次级代谢物（主要是促进微生物与其环境相互作用的细胞外分子）组成。虽然我们对初级代谢及其相互关联的中间体网络的了解是定量和全面的，但我们对细菌次级代谢组的理解仍然存在重大知识差距。在本视角中，我讨论了获得细菌次级代谢组（特别是具有生物合成天赋的微生物）的全局、全面的图片所涉及的主要挑战。将回顾能够应对这些挑战的最新方法论进展。这些方法的应用与持续的创新相结合，将能够详细了解全球次级代谢组，从而揭示天然产物的生物学、化学和酶学，同时有助于药物发现。
Bacterial metabolism is comprised of primary metabolites, the intracellular molecules of life that enable growth and proliferation, and secondary metabolites, predominantly extracellular molecules that facilitate a microbe's interaction with its environment. While our knowledge of primary metabolism and its web of interconnected intermediates is quantitative and holistic, significant knowledge gaps remain in our understanding of the secondary metabolomes of bacteria. In this Perspective, I discuss the main challenges involved in obtaining a global, comprehensive picture of bacterial secondary metabolomes, specifically in biosynthetically gifted microbes. Recent methodological advances that can meet these challenges will be reviewed. Applications of these methods combined with ongoing innovations will enable a detailed picture of global secondary metabolomes, which will in turn shed light onto the biology, chemistry, and enzymology underlying natural products and simultaneously aid drug discovery.