ASSESSMENT OF WALL SHEAR-STRESS IN ARTERIES, APPLIED TO THE CORONARY CIRCULATION
ASSESSMENT OF WALL SHEAR-STRESS IN ARTERIES, APPLIED TO THE CORONARY CIRCULATION
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DOI：
10.1093/cvr/14.10.568
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发表时间：
1980-01-01
影响因子：
10.8
通讯作者：
PEDLEY, TJ
中科院分区：
文献类型：
--
作者：
BENSON, TJ;NEREM, RM;PEDLEY, TJ
使用目前可用的技术不能直接或准确地测量动脉中的时间依赖性壁剪切速率。提出了一种简单的方法，用于计算它们从一个单一的测量速度波形（中心线或横截面平均速度）。该方法涉及傅立叶分析和应用给定的公式，并预计是近似有效的，在任何段的动脉，没有分支或尖锐的曲线，为几个直径的距离。如果在整个循环中得到的壁剪切率波形是准确的，则速度测量装置中需要30 Hz的频率响应，尽管如果仅需要rms [均方根]值，则10 Hz就足够了。这种对精度的限制适用于这种或任何其他估算随时间变化的壁面剪力的方法。该方法适用于预测的壁剪切力在左冠状动脉的马，根据测量的速度，他们是可用的和计算的，他们不是在体内的壁剪切波动的幅度是远远大于平均值。该方法适用于一个缩小模型的马冠状动脉，大概代表的人，在这里的不稳定性是重要的，但不再占主导地位。在动脉粥样硬化形成的背景下，讨论了壁面剪切力随沿着动脉距离的变化。
Time dependent wall shear rates cannot be directly or accurately measured in arteries using presently available techniques. A simple method is presented for calculating them from a single measured velocity waveform (centreline or cross-sectionally averaged velocity). The method involves Fourier analysis and the application of given formulae and is expected to be approximately valid in any segment of artery which has no branches or sharp curves for a distance of several diameters. A frequency response of 30 Hz is required in the velocity measuring device if the resulting wall shear rate waveform is to be accurate throughout the cycle, although 10 Hz is adequate if only the rms [root mean square] value is desired. This restriction on accuracy applies to this or any other method of estimating time-dependent wall shear. The method is applied to a prediction of wall shear in the left coronary arteries of the horse, based on measured velocities where they are available and calculated ones where they are not; in vivo the amplitude of wall shear fluctuations is much greater than the mean. The method is applied to a scaled down model of the horse coronaries, presumably representative of man; here the unsteadiness is important but no longer dominant. The variation of wall shear with distance along the artery is discussed in the context of atherogenesis.