Synthesis, structure, photoluminescence and antitumour activity of zinc complex based on 2-(2-(1H-benzo-[d]imidazol-2-yl)benzyl)-1H-benzo-[d]imidazole
Synthesis, structure, photoluminescence and antitumour activity of zinc complex based on 2-(2-(1H-benzo-[d]imidazol-2-yl)benzyl)-1H-benzo-[d]imidazole
复制标题
2-(2-(1H-苯并-[d]咪唑-2-基)苄基)-1H-苯并-[d]咪唑锌配合物的合成、结构、光致发光及抗肿瘤活性
DOI：
10.1016/j.saa.2014.07.098
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发表时间：
2015
影响因子：
4.4
通讯作者：
Wang Sheng
中科院分区：
文献类型：
--
作者：
Che Zhijian;Wang Shaoxiang;Liu Shenggui;Li Guobi;Wu Qiting;Lin Chunyu;Kong Linglang;Wang Sheng
A new complex [Zn(bbb)Cl2]·DMF, where bbb is 2-(2-(1H-benzo[d]imidazol-2-yl)benzyl)-1H-benzo[d]imidazole, was synthesized and characterized by element analysis,1H NMR and X-ray single crystal structure analyses. For complex: crystal system, triclinic, space group,P–1,a= 9.4661(13),b= 10.3534(14),c= 13.0025(18) Å,α= 73.477(2),β= 80.743(2),γ= 88.658(2)°,V= 1205.5(3) Å3,Z= 2. In this complex, the Zn2+distorted tetrahedron geometry is coordinated by two nitrogen atoms from 2-(2-(1H-benzo[d]imidazol-2-yl)benzyl)-1H-benzo[d]imidazole and two Cl−. The complex emits yellow green luminescence with the maximal emission peak at 550 nm in DMF solution. The complex exhibits inhibition on the growth of Eca109 cancer cell with IC50value of 8.9 ± 1.1 μM, which was lower than that of cisplatin (14.3 ± 1.4 μM). This complex has potential application in treatment of esophageal cancer.
