The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults
The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults
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DOI：
10.1016/j.amjmed.2013.03.002
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发表时间：
2013-07-01
影响因子：
5.9
通讯作者：
Mittleman, Murray A.
中科院分区：
文献类型：
--
作者：
Penner, Elizabeth A.;Buettner, Hannah;Mittleman, Murray A.
背景：关于大麻素与代谢过程之间关系的数据有限。流行病学研究发现，与从未使用过大麻的人相比，大麻使用者的肥胖和糖尿病患病率较低，这表明大麻素与外周代谢过程之间存在关系。到目前为止，没有研究调查大麻的使用和空腹胰岛素，葡萄糖和insulin resistance.METHODS之间的关系：我们包括4657名成年男性和女性从国家健康和营养调查2005年至2010年。在一个私人房间里通过自我报告评估Maritime使用情况。空腹9小时后通过血液样品测量空腹胰岛素和葡萄糖，并计算胰岛素抵抗的稳态模型评估（HOMA-IR）以评估胰岛素抵抗。协会估计使用多元线性回归，占调查设计和调整潜在的confounders.Results：在我们的研究样本的参与者，579是目前的大麻用户和1975年是过去的用户。在多变量校正模型中，目前使用大麻与空腹胰岛素水平降低16%（95%置信区间[CI]，26，6）和HOMA-IR降低17%（95% CI，27，6）相关。我们发现吸食大麻和腰围变小之间有着显著的联系。在目前的用户中，我们没有发现显着的剂量responsibility.CONCLUSIONS：我们发现，大麻的使用与空腹胰岛素和HOMA-IR水平较低，腰围较小。(C)2013 Elsevier Inc. All rights reserved.
BACKGROUND: There are limited data regarding the relationship between cannabinoids and metabolic processes. Epidemiologic studies have found lower prevalence rates of obesity and diabetes mellitus in marijuana users compared with people who have never used marijuana, suggesting a relationship between cannabinoids and peripheral metabolic processes. To date, no study has investigated the relationship between marijuana use and fasting insulin, glucose, and insulin resistance.METHODS: We included 4657 adult men and women from the National Health and Nutrition Examination Survey from 2005 to 2010. Marijuana use was assessed by self-report in a private room. Fasting insulin and glucose were measured via blood samples after a 9-hour fast, and homeostasis model assessment of insulin resistance (HOMA-IR) was calculated to evaluate insulin resistance. Associations were estimated using multiple linear regression, accounting for survey design and adjusting for potential confounders.RESULTS: Of the participants in our study sample, 579 were current marijuana users and 1975 were past users. In multivariable adjusted models, current marijuana use was associated with 16% lower fasting insulin levels (95% confidence interval [CI], 26, 6) and 17% lower HOMA-IR (95% CI, 27, 6). We found significant associations between marijuana use and smaller waist circumferences. Among current users, we found no significant dose-response.CONCLUSIONS: We found that marijuana use was associated with lower levels of fasting insulin and HOMA-IR, and smaller waist circumference. (C) 2013 Elsevier Inc. All rights reserved.