Increased plasma viscosity during an air pollution episode: A link to mortality?
Increased plasma viscosity during an air pollution episode: A link to mortality?
复制标题
DOI：
10.1016/s0140-6736(97)01211-7
复制
发表时间：
1997-05-31
期刊：
影响因子：
168.9
通讯作者：
Koenig, W
中科院分区：
文献类型：
--
作者：
Peters, A;Doring, A;Koenig, W
空气污染事件一直与死亡率增加有关，最引人注目的是与心血管疾病引起的死亡率有关。解释这种关联的一个假设是，污染引起的外周气道炎症可能会增加血液凝固性。我们已经测试了这一假设在一个横断面研究中，通过比较测量血浆粘度在空气污染严重发作期间，在1985年与那些在污染较轻的days.Methods血浆粘度测定的一部分，在1984-85年的冬季，在3256随机选择的男性和女性年龄在25-64岁的莫妮卡奥格斯堡调查。作为巴伐利亚空气质量自动化网络的一部分，在奥格斯堡测量了空气污染物和气象变量的日平均浓度。我们比较了血浆粘度的测量结果在324人谁出席了筛选在污染事件和2932人筛选在其余的调查period.Findings在1985年1月，二氧化硫（平均200微克/立方米）和总悬浮颗粒（平均98微克/立方米）的高浓度，记录在奥格斯堡13天的时间。在男性中，血浆粘度高于分布的第95百分位数（1.38 mPa s）的比值比为3.6（95% CI 1.6-8.1），在调整心血管危险因素和气象变量后，将空气污染事件期间的测量值与非事件测量值进行比较。女性的相应比值比（血浆粘度1.37 mPa s的第95百分位数）为2.3（1.0-5.3）。高浓度的一氧化碳也与血浆粘度增加women.Interpretation在1985年的空气污染事件中，增加的风险的极端值的血浆粘度观察到在男性和女性。因此，由于肺部炎症过程引起的血液流变学改变可能是空气污染与死亡率相关的病理机制的一部分。
Background Air pollution episodes have been consistently associated with increased mortality, and most strikingly with mortality due to cardiovascular disease. One hypothesis to explain this association is that inflammation of the peripheral airways caused by pollution might increase blood coagulability. We have tested this hypothesis in a cross-sectional study by comparing measurements of plasma viscosity during a severe episode of air pollution during 1985 with those made on less polluted days.Methods Plasma viscosity was measured as part of the MONICA Augsburg survey during the winter of 1984-85 in 3256 randomly selected men and women aged 25-64 years. Daily mean concentrations of air pollutants and meteorological variables were measured in Augsburg as part of the automated Bavarian air-quality network. We compared measurements of plasma viscosity made in 324 people who attended for screening during the pollution episode and in 2932 people screened during the remainder of the survey period.Findings In January, 1985, high concentrations of sulphur dioxide (mean 200 mu g/m(3)) and total suspended particles (mean 98 mu g/m(3)) were recorded during a 13-day period in Augsburg. In men, the odds ratio for plasma viscosity above the 95th percentile of the distribution (1.38 mPa s) was 3.6 (95% CI 1.6-8.1) comparing measurements during the air pollution episode with non-episode measurements after adjustment for cardiovascular risk factors and meteorological variables. The corresponding odds ratio for women (95th percentile of plasma viscosity 1.37 mPa s) was 2.3 (1.0-5.3). High concentrations of carbon monoxide were also associated with increased plasma viscosity in women.Interpretation During the 1985 air pollution episode, an increased risk of extreme values of plasma viscosity was observed in both men and women. Altered blood rheology due to inflammatory processes in the lung that induce an acute-phase reaction might therefore be part of the pathological mechanisms linking air pollution to mortality.