Functional connectivity reveals dissociable ventrolateral prefrontal mechanisms for the control of multilingual word retrieval
Functional connectivity reveals dissociable ventrolateral prefrontal mechanisms for the control of multilingual word retrieval
复制标题
DOI：
10.1002/hbm.24788
复制
发表时间：
2019-09-13
影响因子：
4.8
通讯作者：
Paz-Alonso, Pedro M.
中科院分区：
文献类型：
--
作者：
Branzi, Francesca M.;Martin, Clara D.;Paz-Alonso, Pedro M.
这项功能性磁共振成像研究表明，不同部位的腹外侧前额叶皮层（vlPFC）支持反应性和积极主动的语言控制过程中，多语言单词检索。本研究还探讨了主动语言控制是否包括对非目标词汇的抑制。健康的多语种志愿者参与了一项任务，要求他们交替使用主导语言和非主导语言命名图片。两个关键变量被操纵：线索-目标间隔（CTI），以参与（长CTI）或阻止（短CTI）主动控制过程，以及待命名图片的同源状态（非同源与同源）捕获目标语言的选择性预激活。功能连接分析的结果表明，在多语种语言生产过程中，与中vlPFC和前vlPFC相关的功能网络之间存在明显的分离。此外，结果显示，多语者参与主动控制，以准备目标语言。这种前摄性调节是通过激活目标语中的词汇表征来实现的，由前额叶前额叶皮层执行。最后，控制过程的支持下，中vlPFC和左下顶叶，同样从事反应性和主动控制，可能施加在语音表征，以减少跨语言干扰。
This functional magnetic resonance imaging study established that different portions of the ventrolateral prefrontal cortex (vlPFC) support reactive and proactive language control processes during multilingual word retrieval. The study also examined whether proactive language control consists in the suppression of the nontarget lexicon. Healthy multilingual volunteers participated in a task that required them to name pictures alternately in their dominant and less-dominant languages. Two crucial variables were manipulated: the cue-target interval (CTI) to either engage (long CTI) or prevent (short CTI) proactive control processes, and the cognate status of the to-be-named pictures (noncognates vs. cognates) to capture selective pre-activation of the target language. The results of the functional connectivity analysis showed a clear segregation between functional networks related to mid-vlPFC and anterior vlPFC during multilingual language production. Furthermore, the results revealed that multilinguals engage in proactive control to prepare the target language. This proactive modulation, enacted by anterior vlPFC, is achieved by boosting the activation of lexical representations in the target language. Finally, control processes supported by both mid-vlPFC and the left inferior parietal lobe, were similarly engaged by reactive and proactive control, possibly exerted on phonological representations to reduce cross-language interference.