Essential Tremor Is Associated With Disruption of Functional Connectivity in the Ventral Intermediate Nucleus-Motor Cortex-Cerebellum Circuit
Essential Tremor Is Associated With Disruption of Functional Connectivity in the Ventral Intermediate Nucleus-Motor Cortex-Cerebellum Circuit
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DOI：
10.1002/hbm.23024
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发表时间：
2016-01-01
影响因子：
4.8
通讯作者：
Lu, Xiurong
中科院分区：
文献类型：
--
作者：
Fang, Weidong;Chen, Huiyue;Lu, Xiurong
靶向腹侧中间核（VIM）治疗特发性震颤（ET）患者震颤的临床益处表明，VIM是震颤产生和传播网络的关键枢纽，并且VIM可以被视为研究震颤网络的种子区域。然而，人们对 ET 患者的中枢性震颤网络知之甚少。本研究包括 26 名 ET 患者和 26 名匹配的健康对照 (HC)。在考虑结构和头部运动因素并确定种子区域的准确性后，对静息态功能磁共振成像 (RS-fMRI) 数据进行基于 VIM 种子的功能连接 (FC) 分析，以表征 ET 患者的 VIM FC 网络。我们发现 ET 患者和 HC 共享相似的 VIM FC 网络，该网络与从正常非人类灵长类动物和健康人类推断的 VIM 解剖连接网络基本一致。与 HC 相比，ET 患者表现出与 VIM 相关的 FC 变化，主要发生在 VIM-运动皮层 (MC)-小脑 (CBLM) 回路内，其中包括 CBLM 中的 FC 减少和 MC 中的 FC 增加。重要的是，震颤严重程度与这些 FC 变化相关。这些发现提供了第一个证据，表明在 ET 患者中观察到的病理性震颤可能基于生理上预先存在的 VIM - MC - CBLM 网络，并且该生理网络中 FC 的破坏与 ET 相关。此外，这些发现证明了阐明这种疾病背后的神经网络机制的潜在方法。 (C) 2015 年 Wiley 期刊公司。
The clinical benefits of targeting the ventral intermediate nucleus (VIM) for the treatment of tremors in essential tremor (ET) patients suggest that the VIM is a key hub in the network of tremor generation and propagation and that the VIM can be considered as a seed region to study the tremor network. However, little is known about the central tremor network in ET patients. Twenty-six ET patients and 26 matched healthy controls (HCs) were included in this study. After considering structural and head-motion factors and establishing the accuracy of our seed region, a VIM seed-based functional connectivity (FC) analysis of resting-state functional magnetic resonance imaging (RS-fMRI) data was performed to characterize the VIM FC network in ET patients. We found that ET patients and HCs shared a similar VIM FC network that was generally consistent with the VIM anatomical connectivity network inferred from normal nonhuman primates and healthy humans. Compared with HCs, ET patients displayed VIM-related FC changes, primarily within the VIM-motor cortex (MC)-cerebellum (CBLM) circuit, which included decreased FC in the CBLM and increased FC in the MC. Importantly, tremor severity correlated with these FC changes. These findings provide the first evidence that the pathological tremors observed in ET patients might be based on a physiologically pre-existing VIM - MC - CBLM network and that disruption of FC in this physiological network is associated with ET. Further, these findings demonstrate a potential approach for elucidating the neural network mechanisms underlying this disease. (C) 2015 Wiley Periodicals, Inc.