The association between systemic oxidative stress and ocular blood flow in patients with normal-tension glaucoma
The association between systemic oxidative stress and ocular blood flow in patients with normal-tension glaucoma
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DOI：
10.1007/s00417-015-3203-z
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发表时间：
2016-02-01
影响因子：
2.7
通讯作者：
Nakazawa, Toru
中科院分区：
文献类型：
--
作者：
Himori, Noriko;Kunikata, Hiroshi;Nakazawa, Toru
旨在评估眼血流量与全身氧化应激生物标志物之间的关联，以及这些生物标志物评估正常眼压性青光眼 (NTG) 的潜力。本研究纳入了 73 名 NTG 患者的 73 只眼睛。我们通过使用激光散斑血流成像技术测量视神经头的平均模糊率（MBR）来评估眼部血流，包括整体和单独的血管和组织区域。我们还测量了尿液 8-羟基-2'-脱氧鸟苷 (8-OHdG) 和皮肤自发荧光 (SAF)，最后确定了这些测量值与其他临床参数之间的相关性。SAF 与年龄、周围乳头状视网膜神经纤维层厚度 (cpRNFLT)、平均偏差 (MD) 和总体 MBR 相关（P = 0.003、P = 0.013、P = 0.015 和 P = 0.006，分别）。 SAF 和 8-OHdG 均与组织面积 MBR 相关（分别为 P = 0.006 和 P = 0.010）。视力、cpRNFLT、平均偏差和组织面积 MBR 有随 NTG 严重程度而变化的显着趋势（分别为 P = 0.014、P < 0.001、P < 0.001 和 P = 0.006）。多元回归分析显示，cpRNFLT和8-OHdG是MD的独立影响因素（分别为P < 0.001和P = 0.040），cpRNFLT和8-OHdG是组织区域MBR的独立影响因素（分别为P = 0.005和P = 0.028）。我们发现cpRNFLT、MD、组织MBR、SAF和8-OHdG，表明全身氧化应激与眼部血流量减少有关，可能参与 NTG 的发病机制。
To evaluate the association between ocular blood flow and biomarkers of systemic oxidative stress, as well as the potential of these biomarkers to assess normal-tension glaucoma (NTG).This study included 73 eyes of 73 patients with NTG. We assessed ocular blood flow by measuring mean blur rate (MBR) in the optic nerve head using laser speckle flowgraphy, both overall and separately in the vessel and tissue areas. We also measured urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and skin autofluorescence (SAF), and lastly, determined correlations between these measurements and with other clinical parameters.SAF was correlated with age, circumpapillary retinal nerve fiber layer thickness (cpRNFLT), mean deviation (MD), and overall MBR (P = 0.003, P = 0.013, P = 0.015 and P = 0.006, respectively). SAF and 8-OHdG were both correlated with tissue-area MBR (P = 0.006 and P = 0.010, respectively). Visual acuity, cpRNFLT, mean deviation and tissue-area MBR had a significant tendency to change with NTG severity (P = 0.014, P < 0.001, P < 0.001 and P = 0.006, respectively). Multiple regression analysis revealed that cpRNFLT and 8-OHdG were independent contributing factors to MD (P < 0.001 and P = 0.040, respectively), and that cpRNFLT and 8-OHdG were independent contributing factors to tissue-area MBR (P = 0.005 and P = 0.028, respectively).We found a close relationship between cpRNFLT, MD, tissue MBR, SAF and 8-OHdG, suggesting that systemic oxidative stress is associated with decreased ocular blood flow and may be involved in the pathogenesis of NTG.