Vascular effects of free radicals generated by electrical stimulation.
Vascular effects of free radicals generated by electrical stimulation.
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电刺激产生的自由基对血管的影响。
DOI：
10.1152/ajpheart.1984.247.5.h709
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Webb,RC
中科院分区：
文献类型：
--
作者：
Lamb,FS;Webb,RC
对大鼠尾动脉和狗冠状动脉的孤立部分进行电场刺激（9 V，1.0 ms，4 Hz）可抑制对外源性去甲肾上腺素和钾浓度升高的收缩反应。电刺激的这种抑制作用被多种改变氧代谢的物质所阻断：超氧化物歧化酶、过氧化氢酶、谷胱甘肽、抗坏血酸和二甲亚砜。观察结果表明，抑制作用是由于富氧缓冲液的电刺激产生的氧自由基代谢物的作用所致。这些自由基代谢物有两个作用：1）它们氧化实验系统中的药物，2）它们对血管平滑肌发挥直接抑制作用。
Electrical field stimulation (9 V, 1.0 ms, 4 Hz) of isolated segments of rat tail arteries and dog coronary arteries inhibits contractile responses to exogenous norepinephrine and elevated potassium concentration. This inhibitory effect of electrical stimulation is blocked by various agents that alter oxygen metabolism: superoxide dismutase, catalase, glutathione, ascorbate, and dimethyl sulfoxide. The observations suggest that the inhibitory effect is due to an action of oxygen free radical metabolites that are generated by the electrical stimulation of the oxygen-rich buffer. These free radical metabolites have two actions: 1) they oxidize drugs in the experimental system, and 2) they exert a direct inhibitory action on vascular smooth muscle.