Time and length scales of autocrine signals in three dimensions
Time and length scales of autocrine signals in three dimensions
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DOI：
10.1529/biophysj.107.109736
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发表时间：
2007-09-01
影响因子：
3.4
通讯作者：
Shvartsman, Stanislav Y.
中科院分区：
文献类型：
--
作者：
Coppey, Mathieu;Berezhkovskii, Alexander M.;Shvartsman, Stanislav Y.
在有效培养基近似的基础上，建立了悬浮细胞培养中的自分泌信号传导模型。导出了自分泌配体的比例、旁分泌配体结合前的平均和分布距离，以及配体寿命的平均和分布。干扰素信号的树突状免疫细胞被认为是一个例子。
A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration.