Chitosan/fucoidan multilayer coating of gold nanorods as highly efficient near-infrared photothermal agents for cancer therapy
Chitosan/fucoidan multilayer coating of gold nanorods as highly efficient near-infrared photothermal agents for cancer therapy
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DOI：
10.1016/j.carbpol.2019.01.010
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发表时间：
2019-05-01
影响因子：
11.2
通讯作者：
Oh, Junghwan
中科院分区：
文献类型：
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作者：
Manivasagan, Panchanathan;Hoang, Giang;Oh, Junghwan
使用壳聚糖/岩藻依聚糖多层涂层的金纳米棒（CS/F-GNRs）的光热疗法（PTT）已经成为癌症治疗的替代策略。在这项研究中，生物相容性CS/F-GNRs被合成作为新一代光热治疗剂，用于体内癌症治疗，由于其良好的生物相容性，光稳定性和在近红外（NIR）区域的强吸收。CS/F-GNRs具有良好的粒径分布（51.87 +/- 3.03 nm），激光辐照后，CS/F-GNRs的温度变化增加了54.4 CS/F-GNRs的体外光热效率表明，在1.0 W/cm（2）的激光照射下，在治疗的第20天，在激光照射下用CS/F-GNRs治疗的小鼠中的MDA-MB-231肿瘤细胞几乎完全消失。因此，具有生物相容性的CS/F-GNRs作为安全高效的近红外光热剂在未来的癌症治疗中显示出巨大的前景。
Photothermal therapy (PTT) using chitosan/fucoidan multilayer coating of gold nanorods (CS/F-GNRs) has emerged as an alternative strategy for cancer therapy. In this study, biocompatible CS/F-GNRs were synthesized as a new generation of photothermal therapeutic agents for in vivo cancer treatments owing to their good bio-compatibility, photostability, and strong absorption in the near-infrared (NIR) region. The CS/F-GNRs showed a good size distribution (51.87 +/- 3.03 nm), and the temperature variation of the CS/F-GNRs increased by 54.4 degrees C after laser irradiation (1.0 W/cm(2)) for 5 min. The in vitro photothermal efficiency of CS/F-GNRs indicated that significantly more cancer cells were killed under laser irradiation at 1.0 W/cm(2) for 5 min. On the 20th day of treatment, the MDA-MB-231 tumor cells in mice treated with CS/F-GNRs under laser irradiation had almost completely disappeared. Therefore, the biocompatible CS/F-GNRs have shown great promise as safe and highly efficient near-infrared photothermal agents for future cancer therapy.