Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test
Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test
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DOI：
10.1007/s001250051561
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发表时间：
2000-12-01
期刊：
影响因子：
8.2
通讯作者：
Corcoy, R
中科院分区：
文献类型：
--
作者：
Albareda, M;Rodríguez-Espinosa, J;Corcoy, R
目标/假设。我们的目的是找出通过空腹和OGTT测量评估的胰岛素敏感性和β细胞功能之间的关系是否具有生理形态(与参考方法呈双曲线关系)。无糖尿病一级亲属的健康女性接受75g OGTT，分别在0、30、60和120min测定血糖和胰岛素浓度(n=35)。使用前面描述的空腹指数(1个为β细胞功能？6个为胰岛素敏感性)和OGTT测量(3个为β细胞功能，5个为胰岛素敏感性)来评估β细胞功能和胰岛素敏感性。使用非线性回归方法对21个β细胞功能-胰岛素敏感性对进行双曲线关系检验。在7名女性中，无法通过口服葡萄糖耐量试验来评估β细胞功能，其中一名女性的指数为异常值。对于其余27名女性，只有8种组合调整为双曲线关系。以空腹血糖/胰岛素比值作为胰岛素敏感性的估计，以稳态模型评估指数(HOMA)指数(空腹单个样本)作为β细胞功能的估计(r(2)0.802，k 869.71，p<；0.001)获得最佳调整。在这组健康女性中，使用OGTT衍生的葡萄糖和胰岛素测量的大多数方法对胰岛素敏感性和β细胞功能的估计不符合双曲线关系，但所有空腹指数组合都符合双曲线关系。用HOMA指数评价胰岛β细胞功能和用空腹血糖/胰岛素比值评价胰岛素敏感性效果最好。
Aims/hypothesis. We aimed to find if the relation between insulin sensitivity and beta-cell function assessed from fasting and OGTT measurements has a physiological shape (hyperbolic with the reference methods).Methods. Healthy women without diabetic first-degree relatives underwent a 75 g OGTT with plasma glucose and insulin (n=35) concentrations being measured at 0, 30, 60 and 120 min. Beta-cell function and insulin sensitivity were estimated using previously described indices from fasting (1 for beta-cell function? 6 for insulin sensitivity) and OGTT measurements (3 for beta-cell function and 5 for insulin sensitivity). A hyperbolic relation was tested for the 21 beta-cell function-insulin sensitivity pairs using a non-lineal regression method.Results. The assessment of beta-cell function from OGTT was impossible in seven women and one had outlier indices. For the remaining 27 women, only 8 combinations adjusted to a hyperbolic relation. The best adjustment was achieved using the fasting glucose to insulin ratio as the estimation of insulin sensitivity and the homeostasis model assessment (HOMA) index (single fasting sample) as the estimation of beta-cell function (r(2) 0.802, k 869.71, p < 0.001).Conclusion/interpretation. In this group of healthy women, the estimation of insulin sensitivity and beta-cell function by most methods using OGTT-derived glucose and insulin measurements did not adjust to a hyperbolic relation but all fasting indices combinations did. Beta-cell function estimated with the HOMA index and insulin sensitivity with fasting glucose to insulin ratio had the best adjustment.