Transcriptional Regulation of the Immune Receptor FLS2 Controls the Ontogeny of Plant Innate Immunity.
Transcriptional Regulation of the Immune Receptor FLS2 Controls the Ontogeny of Plant Innate Immunity.
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免疫受体 FLS2 的转录调控控制植物先天免疫的个体发育。
DOI：
10.1105/tpc.18.00297
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发表时间：
2018
期刊：
影响因子：
11.6
通讯作者：
Lu Dongping
中科院分区：
文献类型：
--
作者：
Zou Yanmin;Wang Shuangfeng;Zhou Yuanyuan;Bai Jiaojiao;Huang Guozhong;Liu Xiaotong;Zhang Yingying;Tang Dingzhong;Lu Dongping
天然免疫在保护植物和动物免受病原体感染方面起着至关重要的作用。动物和植物的免疫力随年龄而变化。然而，对植物天然免疫在幼苗发育过程中的个体发生知之甚少。我们在此报道了拟南芥（Arabidopsis thaliana）microRNA miR 172 b通过TOE 1和TOE 2调节免疫受体基因FLAGELLIN-SENSING 2（FLS 2）的转录，TOE 1和TOE 2直接与FLS 2启动子结合并抑制其活性。miR 172 b在幼苗发育的早期水平非常低，但随着时间的推移而增加，这导致TOE 1/2蛋白积累减少，从而增加了FLS 2转录和FLS 2介导的免疫在幼苗发育过程中的个体发生。我们的研究揭示了miR 172 b-TOE 1/2模块在调节植物先天免疫中的作用，并阐明了植物先天免疫个体发生的调节机制。
Innate immunity plays a vital role in protecting plants and animals from pathogen infections. Immunity varies with age in both animals and plants. However, little is known about the ontogeny of plant innate immunity during seedling development. We report here that the Arabidopsis (Arabidopsis thaliana) microRNA miR172b regulates the transcription of the immune receptor geneFLAGELLIN-SENSING2(FLS2) through TARGET OF EAT1 (TOE1) and TOE2, which directly bind to theFLS2promoter and inhibit its activity. The level of miR172b is very low in the early stage of seedling development but increases over time, which results in decreased TOE1/2 protein accumulation and, consequently, increasedFLS2transcription and the ontogeny of FLS2-mediated immunity during seedling development. Our study reveals a role for the miR172b-TOE1/2 module in regulating plant innate immunity and elucidates a regulatory mechanism underlying the ontogeny of plant innate immunity.