Wistar rats show episodic-like memory for unique experiences
Wistar rats show episodic-like memory for unique experiences
复制标题
DOI：
10.1016/j.nlm.2005.10.002
复制
发表时间：
2006-03-01
影响因子：
2.7
通讯作者：
Dere, E
中科院分区：
文献类型：
--
作者：
Kart-Teke, E;Silva, MADS;Dere, E
人类的情景记忆是指对所有独特的过去经验的回忆，包括其细节，地点和时间发生。情景记忆，即使在原则上，也很难在非语言哺乳动物中证明。以前，我们提供的证据表明，小鼠能够通过结合不同版本的新奇偏好范式，即，对象识别记忆，对探索对象的位置的记忆，以及对在不同时间点呈现的对象的时间顺序记忆。在目前的一系列实验中，我们评估了这种范式，稍加修改，是否也适用于大鼠。我们发现，相对于“最近熟悉”的物体，老鼠花了更多的时间探索“老熟悉”的物体，这表明它们在单独的试验中识别出了以前探索过的物体，并记住了它们的呈现顺序。同时，大鼠对空间物体位移的反应不同，这取决于“老熟悉”或“最近熟悉”的物体是否被转移到以前没有遇到过的位置。这些结果提供了强有力的证据表明，大鼠建立了一个整合的记忆“什么”，“在哪里”，和“什么时候”。我们还发现，急性应激损害了动物的表现，在情节样的记忆任务，然而，可以部分逆转的N-甲基-D-天冬氨酸受体激动剂D-环丝氨酸。(c)2005年爱思唯尔公司All rights reserved.
Human episodic memory refers to the recollection of all unique past experience in terms of its details, its locale, and temporal occurrence. Episodic memory, even in principle, has been difficult to demonstrate in non-verbal mammals. Previously, We provided evidence that mice are able to form an integrated memory for "what', where", and "when" aspects of single experiences by combining different versions of the novelty-preference paradigm, i.e., object recognition memory, the memory for locations in which objects were explored, and the temporal order memory for objects presented at distinct time points. In the present series of experiments we evaluated whether this paradigm, with minor modifications, also works with rats. We found that rats spent more time exploring an "old familiar" object relative to a "recent familiar" object, suggesting that they recognized objects previously explored during separate trials and remembered their order of presentation. Concurrently, the rats responded differentially to spatial object displacement dependent on whether an "old familiar" or "recent familiar" object was shifted to a location, where it was not encountered previously. These results provide strong evidence that the rats established an integrated memory for "what", "where", and "when". We also found that acute stress impaired the animal's performance in the episodic-like memory task, which, however, could be partially reversed by the N-Methyl-D-aspartate-receptors agonist D-cycloserine. (c) 2005 Elsevier Inc. All rights reserved.