Neural correlates of cognitive bias modification for interpretation
Neural correlates of cognitive bias modification for interpretation
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DOI：
10.1093/scan/nsaa026
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发表时间：
2020-02
影响因子：
4.2
通讯作者：
Kohei Sakaki;Takayuki Nozawa;S. Ikeda;R. Kawashima
中科院分区：
文献类型：
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作者：
Kohei Sakaki;Takayuki Nozawa;S. Ikeda;R. Kawashima
摘要本文研究了认知偏见修正解释（CBM-I）作为一种减轻社交焦虑的治疗方法的有效性。然而，CBM-I的神经相关性尚不清楚，我们的目的是在干预前后比较中阐明干预期间的大脑活动和与CBM-I有效性相关的活动变化。健康参与者分为两组（CBM组和对照组），在干预前、干预中和干预后使用功能磁共振成像进行扫描。在干预期间，CBM组反复想象模棱两可的社会情境，然后是积极的结果，而对照组有一半的结果是消极的。全脑分析显示，干预期间CBM组的体运动区和体感觉区、枕叶、梭状回和丘脑的激活显著高于对照组。此外，在解释模棱两可的社会情境时，躯体运动区、体感觉区、枕叶和扣带回后区活动的改变显示了SA相互作用的显著组x变化。我们的研究结果表明，当面对模棱两可的社会情境时，CBM-I灌输的积极意象被回忆起来，并且解释被修改以包含社会奖励。这些发现可能有助于从认知神经科学的角度提出一种增强CBM-I有效性的替代方法。
Abstract The effectiveness of cognitive bias modification for interpretation (CBM-I), a treatment method employed to reduce social anxiety (SA), has been examined. However, the neural correlates of CBM-I remain unclear, and we aimed to elucidate brain activities during intervention and activity changes associated with CBM-I effectiveness in a pre–post intervention comparison. Healthy participants divided into two groups (CBM, control) were scanned before, during and after intervention using functional magnetic resonance imaging. Ambiguous social situations followed by positive outcomes were repeatedly imagined by the CBM group during intervention, while half of the outcomes in the control group were negative. Whole-brain analysis revealed that activation of the somatomotor and somatosensory areas, occipital lobe, fusiform gyrus and thalamus during intervention was significantly greater in the CBM than in the control group. Furthermore, altered activities in the somatomotor and somatosensory areas, occipital lobe and posterior cingulate gyrus during interpreting ambiguous social situations showed a significant group × change in SA interaction. Our result suggests that when facing ambiguous social situations, positive imagery instilled by CBM-I is recalled, and interpretations are modified to contain social reward. These findings may help to suggest an alternative manner of enhancing CBM-I effectiveness from a cognitive-neuroscience perspective.