Chemistry of the Welwitindolinones
Chemistry of the Welwitindolinones
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DOI：
10.1007/7081_2007_063
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Menendez, J. Carlos
中科院分区：
文献类型：
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作者：
Menendez, J. Carlos
海洋蓝藻是一种生物活性天然产物的丰富来源。良性吲哚啉酮类化合物是从蓝藻中分离得到的一类结构独特的代谢产物，含有3，4-桥连或螺环丁烷羟吲哚基团。由于它们具有挑战性的结构和广泛的生物活性，这些化合物已经吸引了合成化学家的注意一段时间，尽管到目前为止，它们的复杂性阻止了大多数这些天然产物的全合成。本章介绍了吲哚啉酮类化合物的存在、生物学性质、生物合成及合成方法。
Marine cyanobacteria are a prolific source of bioactive natural products. The welwitindolinones are a group of structurally unique metabolites isolated from cyanobacteria, containing 3,4-bridged or spiro cyclobutaneoxindole moieties. Due to their challenging structures and their broad spectrum of biological activities, these compounds have attracted the attention of synthetic chemists for some time, although so far their complexity has prevented the completion of total syntheses for most of these natural products. This chapter is devoted to a discussion of the current knowledge about the occurrence, biological properties, biosynthesis and synthetic approaches to the welwitindolinones.