Mechanisms by Which Pleiotropic Amphiphilic n-3 PUFA Reduce Colon Cancer Risk.
Mechanisms by Which Pleiotropic Amphiphilic n-3 PUFA Reduce Colon Cancer Risk.
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DOI：
10.1007/s11888-014-0241-6
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发表时间：
2014-12-01
影响因子：
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通讯作者：
Fan, Yang-Yi
中科院分区：
文献类型：
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作者：
Chapkin, Robert S;DeClercq, Vanessa;Kim, Eunjoo;Fuentes, Natividad Roberto;Fan, Yang-Yi
结直肠癌是全世界男性和女性癌症相关死亡率的主要原因之一。遗传易感性和饮食是癌症风险和肿瘤行为的主要决定因素。实验、流行病学和临床数据证实了n-3多不饱和脂肪酸（PUFA）在预防慢性炎症和结肠癌方面的有益作用。从机理的角度来看，n-3 PUFA是多效性的，就其分子作用机制而言是多方面的。例如，这类膳食脂质独特地改变了膜结构/细胞骨架功能，影响膜受体功能和下游信号级联，包括基因表达谱和细胞表型。此外，n-3 PUFA可以与其他潜在的抗肿瘤药物协同作用，如可发酵纤维和姜黄素。随着饮食引起的肥胖症的流行率上升，也迫切需要阐明脂肪组织中的慢性炎症与肥胖症中的结肠癌风险之间的联系。在这篇综述中，我们将总结最近的发展联系n-3多不饱和脂肪酸的摄入，膜的改变，表观遗传调制，和肥胖相关的结肠癌风险的影响。
Colorectal cancer is one of the major causes of cancer-related mortality in both men and women worldwide. Genetic susceptibility and diet are primary determinants of cancer risk and tumor behavior. Experimental, epidemiological, and clinical data substantiate the beneficial role of n–3 polyunsaturated fatty acids (PUFA) in preventing chronic inflammation and colon cancer. From a mechanistic perspective, n–3 PUFA are pleiotropic and multifaceted with respect to their molecular mechanisms of action. For example, this class of dietary lipid uniquely alters membrane structure/ cytoskeletal function, impacting membrane receptor function and downstream signaling cascades, including gene expression profiles and cell phenotype. In addition, n–3 PUFA can synergize with other potential anti-tumor agents, such as fermentable fiber and curcumin. With the rising prevalence of diet-induced obesity, there is also an urgent need to elucidate the link between chronic inflammation in adipose tissue and colon cancer risk in obesity. In this review, we will summarize recent developments linking n–3 PUFA intake, membrane alterations, epigenetic modulation, and effects on obesity-associated colon cancer risk.