Spatial congruence of neuronavigated transcranial magnetic stimulation and functional neuroimaging
Spatial congruence of neuronavigated transcranial magnetic stimulation and functional neuroimaging
复制标题
DOI：
10.1016/s1388-2457(02)00026-3
复制
发表时间：
2002-04-01
影响因子：
4.7
通讯作者：
Schönfeldt-Lecuona, C
中科院分区：
文献类型：
--
作者：
Herwig, U;Kölbel, K;Schönfeldt-Lecuona, C
目标：经颅磁刺激（TMS）作为认知神经科学和临床研究的工具正在逐渐获得相关性。然而，该领域的大多数研究并未考虑个体解剖学。神经导航设备可以将线圈引导至由功能磁共振成像 (fMRI) 预先确定的特定皮质区域。因此，了解 fMRI 识别的特定功能区域是否对应于 TMS 应该放置的区域以影响该功能至关重要。 方法：我们使用 5 X 5 mm 的间距，研究了 8 名受试者在 fMRI 中运动任务激活的皮质区域与磁诱发运动电位 (MEP) 区域之间的空间关系。神经导航系统适应切割、线圈定位和刺激坐标的注册。结果：发现 fMRI 和 MEP 的重心空间发散，平均距离约为 10 毫米，MEP 中心的平均偏差为 7.5 毫米，始终位于 fMRI 激活中心之前。然而，关于 MEP 区域和 fMRI 活动，发现 110% 和 120% 运动阈值的刺激强度存在很大重叠。结论：MIRI 和神经导航 TMS 的结合对于 fMRI 预先确定的个体皮质功能的非侵入性研究非常有用。尽管两者在空间上大体上一致，但 MEP 和 fMRI 区域之间确切空间关系的差异应予以考虑并进一步研究。 (C) 2002 Elsevier Science Ireland Ltd. 保留所有权利。
Objectives: Transcranial magnetic stimulation (TMS) is progressively gaining relevance as a tool in cognitive neuroscience and clinical research. However, most studies in this field do not consider individual anatomy. Neuronavigational devices allow to guide the coil to a specific cortical area, predetermined by functional magnetic resonance imaging (fMRI). Therefore, it is crucial to know whether the area of a certain function as identified by fMRI corresponds to the area where the TMS should be placed in order to influence this function.Methods: We investigated the spatial relation between the cortical area activated by a mator task in fMRI and the area of magnetically evoked motor potentials (MEP) in 8 subjects, using a spacing of 5 X 5 mm. A neuronavigational system was adapted Cut, coil positioning and for the registration of the stimulation coordinates.Results: A spatial divergence of the centers of gravity from fMRI and MEP was found with a mean distance of about 10 mm, with the MEP centers being, by a mean derivation of 7.5 mm, consistently anterior to the center of fMRI activation. However, regarding MEP areas and fMRI activities, a large overlap was found for stimulation intensities of both 110 and 120% motor threshold.Conclusions: The combination of MIRI and neuronavigated TMS is useful for non-invasive investigation of individual cortical functions predetermined by fMRI. Whereas both are spatially by and large congruent, discrepencies in the exact spatial relation between MEP and fMRI areas should be considered and further studied. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.