Regional pulmonary transit times in humans.
Regional pulmonary transit times in humans.
复制标题
人类的区域肺传输时间。
DOI：
10.1152/jappl.1989.66.2.844
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发表时间：
1989
影响因子：
3.3
通讯作者：
James C. Hogg
中科院分区：
文献类型：
--
作者：
William MacNee;B. Martin;B. Wiggs;Allan S. Belzberg;James C. Hogg
我们测量了 8 名因周围肺肿瘤接受开胸手术的受试者的肺叶中红细胞 (RBC) 转运时间的频率分布。通过注射放射性标记的血流和体积标记来测量红细胞传输时间，这些标记在切除的肺样本中进行计数。在其中五名受试者中，将切除肺部的测量结果与术前使用伽马相机计算机系统测量的放射性标记红细胞的传输时间进行了比较。获得心室和肺或其区域的时间-活动曲线，通过质心和反卷积技术计算通过时间。在连续推注放射性标记细胞后，在另外八名正常受试者中评估了通过该技术测量的通过时间的再现性。术前研究中上肺区域的平均通过时间（5.1 +/- 0.5 s）长于下肺区域的平均通过时间（4.1 +/- 0.6 s，P小于0.05）。同样，在切除的肺标本中，上肺切片的平均通过时间（5.5 +/- 0.3 s）比下肺切片的平均通过时间（3.8 +/- 0.3 s，P小于0.05）长。我们的结论是，这些技术之间有很好的一致性，并且人肺上部区域的传输时间很长。
We measured the frequency distribution of erythrocyte (RBC) transit times in resected lobes of lungs in eight human subjects undergoing thoracotomy for peripheral lung tumors. RBC transit times were measured by the injection of radiolabeled blood flow and volume markers, which were counted in samples from the resected lung. In five of these subjects, the measurements from the resected lung were compared with preoperative measurements of the transit times of radiolabeled RBCs with a gamma camera-computer system. Time-activity curves from the cardiac chambers and the lung or its regions were obtained from which transit times were calculated by the centroid and deconvolution techniques. The reproducibility of transit times measured by this technique was assessed in another eight normal subjects, after sequential bolus injections of radiolabeled cells. The mean transit time of the upper lung region was longer (5.1 +/- 0.5 s) than that of the lower (4.1 +/- 0.6 s, P less than 0.05) in the preoperative study. Similarly, the mean transit time of the upper lung slice was longer (5.5 +/- 0.3 s) than that of the lower slice (3.8 +/- 0.3 s, P less than 0.05) in the resected lung specimens. We conclude that there was good agreement between these techniques and that there are long transit times in the upper regions of human lungs.