Essential role of vasopressin-regulated urea transport processes in the mammalian kidney
Essential role of vasopressin-regulated urea transport processes in the mammalian kidney
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DOI：
10.1007/s00424-008-0612-4
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发表时间：
2009-05-01
影响因子：
4.5
通讯作者：
Fenton, Robert A.
中科院分区：
文献类型：
--
作者：
Fenton, Robert A.
尿素穿过质膜的运动由专门的尿素转运蛋白调节。已克隆了两个尿素转运蛋白基因：UT-A（Slc 14 a2）和UT-B（Slc 14 a1）。在哺乳动物肾脏中，尿素转运蛋白对于尿浓缩机制和维持体液稳态是必需的。本文综述了尿素转运机制的历史研究概况，尿素转运蛋白调控的最新研究进展，UT-A1/3（-/-）小鼠的生理学研究，尿素转运蛋白在尿浓缩机制中的重要作用，尿素转运蛋白在尿浓缩机制中的作用，以及尿素转运蛋白在尿浓缩机制中的作用。和（4）在UT-A2和UT-B敲除小鼠中的生理学研究，检查逆流交换在产生最大浓缩尿中的作用。
Movement of urea across plasma membranes is modulated by specialized urea transporter proteins. Two urea-transporter genes have been cloned: UT-A (Slc14a2) and UT-B (Slc14a1). In the mammalian kidney, urea transporters are essential for the urinary concentrating mechanism and maintaining body fluid homeostasis. In this article, we discuss (1) an overview of historic discoveries in urea transport mechanisms; (2) an overview of recent discoveries in the regulation of urea transporters; (3) physiological studies in UT-A1/3 (-/-) mice highlighting the essential role of urea transporters in the urinary concentrating mechanism; and (4) physiological studies in UT-A2 and UT-B knockout mice examining the role of countercurrent exchange in the production of a maximally concentrated urine.